摘要
目的:观察用血液稀释加川芎嗪治疗脑外伤患者的临床效果。方法:选取2012年4月—2014年3月于我院就诊的脑外伤患者94例,随机分为对照组和治疗组患者各47例。两组患者入院后均给予常规吸氧、降颅内压、营养、抗生素、脱水等基础治疗;治疗组患者则在对照组治疗的基础上给予血液稀释加川芎嗪治疗,连续治疗10 d。观察两组患者治疗后的临床症状缓解情况,用神经功能缺损程度评分量表NIHSS、格拉斯哥昏迷量表GCS、格拉斯哥预后量表GOS对患者的神经功能缺损程度、昏迷严重程度、预后情况进行评价;检测患者治疗前后血清hs-CRP、IL-1β、IL-6等炎性因子水平的变化及血浆一氧化氮(NO)、超氧化物歧化酶(SOD)含量。结果:两组患者临床症状均得到缓解,神经功能有所提高、昏迷情况有所改善,预后良好,神经功能缺损程度NIHSS评分有所降低,格拉斯哥昏迷量表GCS评分有所升高,以治疗组的改善尤为突出,治疗组的预后GOS评分更高,差异有统计学意义(P<0.05);治疗后两组患者的血清hs-CRP、IL-1β、IL-6炎性因子水平均较同组治疗前有所下降,以治疗组的下降更为突出,差异有统计学意义(P<0.05);治疗后两组患者的血浆一氧化氮(NO)水平有所降低,超氧化物歧化酶(SOD)含量有所升高,变化幅度以治疗组尤为明显,差异有统计学意义(P<0.05)。结论:血液稀释加川芎嗪能有效缓解脑外伤患者的临床症状,改善神经功能,降低炎性因子水平,降低血浆NO活性,提高SOD水平,预后良好,值得临床深入研究运用。
Objective：To investigate the clinical efficacy of treating craniocerebral injury patients with hemodilution and ligustrazine. Methods：94 cases were randomly divided into a control group of 47 cases and a treatment group of 47 cases from April 2012 and March 2014.Patients in the control group were treated with conventional western medicine foundation treatment,such as oxygen,reducing intracranial pressure,nutrition,antibiotics and dehydration;while patients in the treatment group were treated with hemodilution and ligustrazine,10 days for treatment. We observed the improvement of clinical symptoms,and the improvement of nerve function,coma,prognosis,which were evaluated by NIHSS,GCS and GOS. We tested the level change of hs-CRP,IL-1β,IL-6,NO and SOD. Results：After treatment,the main symptoms of the patients were improved clearly compared with before treatment,the nerve function and coma were improved,and the prognosis was good. The NIHSS score went down compared with before treatment,the GCS score went up compared with before treatment,the degree of change in the treatment group was more pronounced,the GOS sores of the treatment group were higher than that of the control group,the difference is significant（P0.05）;The level of hs-CRP,IL-1βand IL-6 went up clearly before treatment,the degree of change in the treatment group was more pronounced,the difference is significant（P0.05）;The level of NO went down clearly before treatment,but the level of SOD went up clearly,and the degree of change in the treatment group was more pronounced,the difference is significant（P0.05）. Conclusion：Treating craniocerebral injury patients with hemodilution and ligustrazine can improve the clinical symptoms,improve the neural function,low the level of inflammatory factor and NO liveness,increase the level of SOD,which have good prognosis effect,is worthy of further research and development.
出处
《辽宁中医药大学学报》
CAS
2015年第7期91-93,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
河北省唐山市科技项目(20100134)
关键词
血液稀释
川芎嗪
脑外伤
临床研究
hemodilution
ligustrazine
craniocerebral injury
clinical research
