摘要
目的探讨血清降钙素原(PCT)、白介素-6(IL-6)及C反应蛋白(CRP)对乙型肝炎肝硬化并发自发性细菌性腹膜炎(SBP)的诊断价值。方法根据腹水性质,将我院住院的150例乙型肝炎肝硬化腹水患者分为SBP组90例,非SBP组60例,并选择同期健康体检者50例作为对照组,检测血清PCT、IL-6和CRP,利用ROC曲线分析PCT、IL-6和CRP对SBP的诊断价值。结果 1)血清PCT在SBP组、非SBP组、对照组分别为(0.78±0.59)ng/mL、(0.18±0.16)ng/mL、(0.05±0.03)ng/mL,SBP组高于非SBP组和对照组(P值均<0.05),非SBP组与对照组之间的差异无统计学意义(P>0.05)。2)血清IL-6及CRP在SBP组分别为(87.89±43.33)pg/mL及(40.53±31.98)mg/mL,非SBP组分别为(41.90±25.38)pg/mL及(13.29±11.33)mg/L,对照组分别为(5.23±12.13)pg/mL及(3.13±2.24)mg/L,SBP组血清IL-6及CRP均高于非SBP组和对照组(P值均<0.05),非SBP组血清IL-6及CRP亦高于对照组(P值均<0.05)。3)PCT在ROC曲线下面积为0.903,较IL-6及CRP在ROC曲线下面积大(分别为0.721及0.674)(P<0.05),而IL-6与CRP在ROC曲线下面积的差异无统计学意义(P>0.05);以PCT、IL-6和CRP作为诊断指标来判断SBP,最佳临界值分别为0.63ng/mL、72.58pg/mL和38.87mg/L,所对应的灵敏度分别为90.1%、83.4%和88.2%,特异度分别为82.9%、76.3%和67.5%。结论血清PCT、IL-6及CRP对乙型肝炎肝硬化并发SBP有一定的参考价值,而以PCT的诊断价值最大。
Objective To investigate the diagnosis value of serum calcitonin （PCT）, interleukin 6 （IL-6） and C-reactive protein （CRP） in spontaneous bacterial peritonitis （SBP） complicated by hepatitis B virus-related cirrhosis. Methods A total of 150 cases of hepatitis B virus-related cirrhosis and ascites were divided into two groups according to the nature of ascites （n=90 with SBP and n=60 without SBP）, and 50 healthy individuals were analyzed as control group. The serum PCT, IL-6 and CRP were detected. Receiver operating characteristic （ROC） curves were used to compare the diagnostic values of PCT, IL-6 and CRP in SBP. Results 1） The serum PCT in SBP group [ （0.78 4-0.59） ng/mL] was higher than that in non-SBP group E （0.18±0.16） ng/mL] and control group [- （0. 054-0.03） ng/mL] （all P〈0.05）, and there were no significant differences between non-SBP group and control group. 2） The serum IL-6 and CRP in SBP group [- （87.89＋43.33） pg/mL and （40.53±31.98） mg/mL, respectively] were higher than those in non-SBP group [（41.90±25.38） pg/mL and （13.29±11.33） mg/L, respectively] and control group [ （5.23±12.13） pg/mL and （3.13±2.24） mg/L, respectively-] （all P〈0.05）, the serum IL- 6 and CRP in non-SBP group were also higher than those in control group （all P〈0.05） . 3） The area under the curve （AUC） for the serum PCT was 0. 903 and bigger than that for the serum IL-6 and CRP （0. 721 and 0. 674, respectively）. Using cut-off points of 0.63 ng/mL for PCT, 72.58 pg/mL for IL-6 and 38.87 mg/L for CRP, the respective sensitivities for diagnosis of SBP were 90. 1%, 83.4% and 88.2%, and the respective speeificities were 82.9 %, 76.3% and 67.5%. Conclusion Serum PCT seems to be better marker than IL-6 and CRP for the diagnosis of hepatitis B virus-related cirrhosis patients with SBP.
出处
《福建医药杂志》
CAS
2015年第3期67-70,共4页
Fujian Medical Journal
基金
福州市卫生系统科技计划项目(2014-S-w15)
