摘要
目的：探讨急性缺血性脑卒中患者入院时不同尿酸水平与出院结局的关系。方法采用回顾性队列研究的方法，连续性纳入内蒙古兴安盟人民医院2009年6月1日-2012年5月31日的全部急性缺血性脑卒中患者为研究对象，共计3440例。结局不良定义为发生残疾或住院期间死亡。残疾的定义参照（modified rankin’s scale，MRs）脑卒中量表，评分在3分及其以上者（MRs≥3）定义为残疾。采用尿酸水平的百分位数 P20，P60和 P90为界点将研究对象分为4组，危险因素的分析采用两分类非条件 logistic 回归方法，计算比值比（odds ratio，OR）及95％可信区间（95％ confident interval，95％CI）。所有检验均为双侧检验，检验水准α＝0.05。结果研究对象中发生不良结局的共359人，占10.44％。单因素 lo-gistic 回归分析显示，相对最低分位组（UA≤222.6 mmol／L），处于二，三分位组（UA 水平为222.7-310.9 mmol／L 和311.0-419.7 mmol／L）发生结局不良的 OR（95％CI）为0.70（0.53-0.91）（P ＜0.05）和0.66（0.49-0.88）（P ＜0.05）。最高分位组相对最低分位组 OR 值无统计学差异。在调整了年龄、体温、高血压、高血糖、脑卒中病史、高三酰甘油、高低密脂蛋白胆固醇和吸烟后，相对于最低分位组，依然有处于二，三分位组发生结局不良的 OR（95％CI）为0.70（0.53-0.93）（P ＜0.05）和0.66（0.48-0.90）（P ＜0.05）。最高分位组相对最低分位组 OR 值差异无统计学意义。结论急性缺血性脑卒中患者入院时较高的尿酸水平可能独立的与出院结局良好有关联。
Objective To examine the association between uric acid （UA）levels of patients with acute ischemic stroke at ad-mission and discharged outcome.Methods The acute ischemic stroke patients of Xinganmeng People’s Hospital in Inner Mongolia,from June 1,2009 to May 31,2012 were continuity included in the present study,the included analysis sample size were 3 440 cases.Poor discharged outcome was defined as the occurrence of disability or death.With reference to the Modi-fied Rankin＇s Scale （MRs）Stroke Scale,Scores were recorded in the questionnaires,score of 3 or more （MRs≥3）was de-fined as disability.The patients were all grouped by P20,P60,P90 of UA,binary logistic regression were used in studying of risk factors,calculated the odds ratios （Odds ratio,OR）and 95% confidence interval （95% Confident interval,95%CI）.All tests were two-sided test and a significance level of 0.05.Results A total of 359 people occurred poor outcomes in the stud-y,accounting for 10.44%.Univariate logistic regression analysis of poor outcome occurred showed that relative to the lowest group（P20,UA≤222.6 mmol/L）,the second and third group （UA：222.7 - 310.9 mmol/L and 311.0-419.7 mmol/L） OR （95% CI）were：0.70（0.53-0.91）（P 〈0.05）and 0.66（0.49-0.88）（P 〈0.05）.After adjusted age,body tempera-ture,high blood pressure,hyperglycemia,history of stroke,high triglycerides,high LDL-C and smoking,relative to the low-est level group,the second and third group occurred poor outcoming OR （95% CI）were：0.70（0.53-0.93）（P 〈0.05）and 0.66（0.48-0.90）（P 〈0.05）.Conclusion Higher levels of uric acid levels in patients with acute ischemic stroke may inde-pendently related with occurred poor discharged outcome.
出处
《现代检验医学杂志》
CAS
2015年第3期17-20,共4页
Journal of Modern Laboratory Medicine
基金
国家自然科学基金（项目批准号：81172760）.
关键词
急性缺血性脑卒中
尿酸
出院结局
acute ischemic stroke
uric acid
discharged outcome
