摘要
目的：观察恩替卡韦治疗HBe Ag阳性慢性乙型肝炎48周后乙肝病毒血清标志物含量与HBV-DNA含量的关系。方法：选取2011年3月~2013年6月期间于本院就诊的HBe Ag阳性慢性乙型肝炎患者58例,给予恩替卡韦0.5 mg口服,1次/d,随访48周。结果：经过48周恩替卡韦治疗后ALT复常率77.59%,HBV-DNA转阴率72.41%,HBe Ag转阴率39.66%,HBe Ag血清转换率27.59%。治疗过程中HBe Ag、HBV-DNA定量值均呈下降趋势,随着治疗时间的延长,HBe Ag、HBV-DNA定量值持续下降,两者之间存在显著的正相关性,且具有统计学意义（R=0.801,P〈0.05）;但HBs Ag定量与血清HBe Ag、HBV-DNA变化水平之间无显著关系（P〉0.05）。结论：恩替卡韦有明显抑制血清HBV-DNA复制和提高HBe Ag血清学转换的作用,HBe Ag基线水平可以预测恩替卡韦治疗HBe Ag阳性慢性乙肝患者的HBe Ag血清学转换率。HBe Ag含量变化与HBV-DNA含量变化存在显著的正相关性,HBs Ag含量变化与HBV-DNA含量变化无明显相关性。
Objective： To investigate the relationship of serum markers of hepatitis B virus and HBV-DNA contents after 48 weeks＇ entecavir therapy in the treatment of HBeAg positive chronic hepatitis B. Methods： From March 2011 to June 2013, 58 patients of HBeAg positive chronic hepatitis B in our hospital were given the entecavir （0.5 mg/d） orally, and they were followed up for 48 weeks. Results： After 48 weeks of treatment, the recovery rate of ALT was 77.59%, the negative conversion rate of HBV-DNA was 72.41%, the negative conversion rate of HBeAg was 39.66%, and the seroconversion rate of HBeAg was 27.59%. In the course of treatment, HBeAg and HBV-DNA quantitative value decreased, and with the extension of treatment time, HBeAg and HBV-DNA quantitative value continued to decline. Obviously, there was a significant positive correlation between the two factors and it showed statistical significance （R=0.801, P〈0.05）; but there was no significant relationship between HBsAg quantitative and serum HBeAg, HBV-DNA levels （P〉0.05）. Conclusion： Entecavir can inhibit the replication of HBeAg and increase serum ITBV-DNA serological conversion function; and the baseline of HBeAg levels can predict HBeAg seroconversion rate of HBeAg positive chronic hepatitis B patients in the treatment of entecavir. Changes of HBV-DNA content and HBeAg content show a significant positive correlation, and there is no significant correlation between changes in HBV-DNA content and HBsAg content.
出处
《实用中西医结合临床》
2015年第4期4-5,44,共3页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
