摘要
目的了解徐州地区耐药结核的流行情况及其耐药谱，探讨耐药结核发生的影响因素。方法选择本院收治的涂阳肺结核患者作为研究对象，采用统一设计的调查表获取患者的基本信息和相关流行病学资料；对研究对象的痰标本进行一线和二线抗结核药物敏感性试验，获取耐药性资料；数据录入Excel表格，采用SPSS18．0软件进行统计分析。结果本地区总的耐药率为17．29％，耐多药[至少同时耐异烟肼（INH）和利福平（RFP）]率为5．60％，广泛耐药率为0．26％；复治患者的耐药率（37．26％）高于初治患者（13．56％），两者差异有统计学意义（X2=140．35，P〈0．05）；单一耐药的菌株中耐INH的耐药率最高，在多耐药（对至少两种一线抗结核药耐药，但不包括同时耐INH和RFP）组合中，以INH＋SM（链霉素）的组合构成比最高；耐多药组合中，以INH＋RFP的组合构成比最高；耐药结核病在不同性别患者中分布的差异无统计学意义，在不同年龄患者中分布具有统计学意义，以41～60岁年龄组耐药率最高。结论徐州地区结核病总耐药率虽然不高，但耐多药率较高，性别分布差异无统计学意义，年龄分布以41～60岁年龄段最多。
Objective To investigate the drug-resistant tuberculosis （TB） in Xuzhou area. epidemic characteristics, spectrum and related factors of Methods Sputum smear-positive patients with TB were selected from Xuzhou Infectious Hospital, the basic information and related epidemiological data of the patients were collected from questionnaire. The first-line and second-line anti-TB drugs sensitivity test was performed. Results The overall rate of resistance to anti-TB drugs was 17.29%. MDR rate was 5.60% and XDR rate was 0.26%. The resistance rates in retreated patients were higher than in initial patients. The single- resistant rate to INH took the highest proportion among all the drugs, the form 1NH ＋ SM accounted for the largest proportion in multi-resistance, the form INH ＋ RFP accounted for the largest proportion in XDR. The distribution of drug-resistant TB showed no statistically significant difference in different gender, but there was statistically significant difference in different age groups： drug resistance rate was significant higher in 41-60 years group than in other age groups. Conclusions The overall drug-resistance rate in Xuzhou was low, but MDR situation was serious. The distribution difference in different gender, drug resistance rate was of drug-resistant TB showed no statistical significance higher in 41-60 years group than in other age groups.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2015年第3期47-51,共5页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金
江苏省"科教兴卫"医学重点人才培养基金(No.RC2011117)
江苏省"六大人才高峰"项目(No.2011-WS-068)
徐州市科技局社会发展基金(No.KC14SH054)
关键词
结核分枝杆菌
耐药
流行病学分析
Mycobacterium tuberculosis
Drug-resistant
Epidemiology analysis
