摘要
目的探讨卵巢恶性中胚叶混合瘤(MMMT)临床病理特点、鉴别诊断及临床治疗和预后。方法回顾性分析重庆市万州区第一人民医院1985年1月至2013年12月收治的9例MMMT患者临床病理资料,行常规石蜡切片HE染色、特殊染色和免疫组织化学染色。结果 B超检查结果显示8例患者为一侧卵巢肿块,1例患者为双侧卵巢肿块。组织学检查,上皮成分为子宫内膜样腺癌5例,透明细胞癌3例,黏液腺癌1例;间叶成分细胞呈梭形或不规则形,编织状或束状排列,或杂乱无章,其中4例可见软骨肉瘤成分,2例可见骨肉瘤成分;9例患者腺上皮细胞角蛋白(CK)检测均为阳性+,间质成分波形蛋白(vimentin)检测均为+;其中有3例雌激素受体(ER)检测为+;2例孕激素受体(PR)检测为+;2例结蛋白(desmin)+;1例高度糖基化的i型跨膜糖蛋白(CD34)检测为+。结论组织学形态是MMMT诊断的主要依据,同时B超和CA125联合检查,能够使其临床诊断的准确率得到有效提高。
Objective To investigate the clinical pathologic features of ovarian malignant mesoderm mixed tumor （malignant mixed mesodermal tumor of uterus ,MMMT ） ,and its differential diagnosis ,clinical treatment and prognosis .Methods A retrospec‐tive analysis of the clinicopathological data of 9 patients with MMMT in our hospital from January 1985 to December 1985 was per‐formed ,and the clinicopathological data included routine paraffin section of HE staining and special staining and immunohistochemi‐cal study .Results Results showed that 8 cases were examined by ultrasound with side ovarian tumor ,1 case of patients with bilat‐eral ovarian tumors .Histological examination showed that there was 5 cases of endometrial carcinoma in epithelial components ,3 ca‐ses in clear cell carcinoma ,1 case in mucous adenocarcinoma .Composition of mesenchymal cells were fusiform or irregular shape , weaving or beam pattern ,or chaotic ,which 4 cases showed chondrosarcoma ,2 cases showed bone sarcoma component and glandular epithelial cell keratin and stromal elements vimentin （Cytokeratin ,CK） of 9 cases were ＋ ,and estrogen receptor （estrogen recep‐tor ,ER） detection of 3 cases were ＋ ,Progesterone receptor（PR） detection of 2 cases were ＋ ,protein （desmin） of 2 cases were ＋ ;highly glycosylation type I transmembrane glycoprotein （CD34） of 1 case was ＋ .Conclusion Histological appearance is the main detection methods of ovarian malignant germ layer in the diagnosis of mixed tumor ,and B ultrasonic and CA125 inspection at the same time can effciently improve the accuracy of clinical diagnosis .
出处
《重庆医学》
CAS
北大核心
2015年第18期2496-2498,共3页
Chongqing medicine
关键词
卵巢
混合瘤
中胚层
病理过程
ovary
mixed tumor,mesodermal
pathological processes
