摘要
目的探讨不同浓度高渗盐水(Hypertonic Saline,HS)对脑水肿患者血生化及渗透压的影响。方法将60例入选患者随机分为3%HS组、7.5%HS组和甘露醇组。3组分别注入3%HS、7.5%HS和20%甘露醇,均为2 m L/kg。比较各组患者治疗前后血生化及渗透压的变化。结果 7.5%HS组和20%甘露醇组治疗后2 h及22 h的血钠、血氯浓度及血浆晶体渗透压较治疗前明显增高(p<0.05)。与3%HS组比较,7.5%HS组和20%甘露醇组治疗后2 h及22 h的血钠、血氯浓度及血浆晶体渗透压明显增高(p<0.05)。结论 3%HS对血生化及晶体渗透压的影响更小,更适用于脑水肿患者的治疗,值得在临床上推广应用。
Objective To explore the effect of different concentrations of hypertonic saline for cerebral ede- ma on blood biochemical and osmotic pressure. Methods 60 cases were randomly divided into the 3% HS group, 7.5% HS group and the mannitol group. The patients were randomly assigned to infusion of 3% HS, 7.5% HS or 20% mannitol （all 2 mL/kg）. Blood biochemical and osmotic pressure on patients were measured before and after the treatment among groups. Results Serum Na ＋ , C1- and osmotic pressure were significantly higher at 2 hours and 22 hours of reperfusion than at baseline （p 〈0.05 ） in the 7.5% HS group and the mannitol group. The difference were significant on serum Na＋ , CI- and osmotic pressure at 2 hours and 22 hours of reperfusion in the 7.5% HS group and the mannitol group than in the 3% HS group （p 〈 0.05 ）. Conclusion 3% hypertonic saline had less effects on blood biochemical and osmotic pressure than other groups for patients of cerebral edema. It is worthy of popularization and applieation.
出处
《现代医院》
2015年第6期5-7,共3页
Modern Hospitals
关键词
高渗盐水
脑水肿
血生化
渗透压
Hypertonic saline
Cerebral edema
Blood biochemical
Osmotic pressure
