摘要
高脂血症是导致动脉粥样硬化形成的主要因素。高脂血症通过作用于血小板,影响其活化、聚集等作用,进而影响动脉血栓形成。而采用他汀干预高脂血症后可改善血小板的活化功能,提示高脂血症与血小板活化密切相关。低密度脂蛋白胆固醇及高密度脂蛋白胆固醇可通过作用于血小板活化通路而影响血小板的活化聚集。该文就近年来高脂血症与血小板活化关系的研究进展予以综述。
Hyperlipidemia is the main factor of the formation of atherosclerosis.Moreover, hyperlipidemia effects on platelet,influences the function of activation and aggregation,therefore influences the formation of atherosclerosis.By administration of statin to hyperlipidemia,it improves the platelet function,which indicates that hyperlipidemia is highly associated with platelet activation .Low-density lipoprotein cholesterol and high-density lipoprotein cholesterol influence platelet function through the impact of platelet signaling pathways . Here is to make review of the research progress of correlation between hyperlipidemia and platelet activation in recent years.
出处
《医学综述》
2015年第11期1948-1951,共4页
Medical Recapitulate
基金
上海市卫生局科研课题计划(20114273)
关键词
高脂血症
血小板活化
低密度脂蛋白胆固醇
高密度脂蛋白胆固醇
Hyperlipidemia
Platelet activation
Low-density lipoprotein cholesterol
High-density lipoprotein cholesterol
