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医院慢性丙型病毒性肝炎患者进展性肝纤维化的发生率及影响因素研究 被引量:1

The incidence rate of progressive hepatic fibrosis and related influential factors on patients with chronic hepatitis C in hospital
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摘要 目的了解医院慢性丙型病毒性肝炎(简称"丙肝")患者的进展性肝纤维化的发生率和影响因素。方法在北京、河南、吉林、辽宁四个省(直辖市)的4家综合医院中,选取在治的慢性丙肝患者进行问卷调查,内容包括研究对象一般人口学特征、感染途径、行为学特征、治疗情况,并结合病历收集患者的实验室检测等结果。结果共调查慢性丙肝患者359例,其中男性171例(47.6%),女性188例(52.4%),平均年龄(55.1±11.9)岁。有进展性肝纤维化者为218例,发生率为60.7%。多因素Logistic回归分析发现,≥40岁、男性、酒精摄入量≥50克/天、未接受抗病毒治疗、合并感染艾滋病病毒(HIV)/乙型肝炎病毒(HBV),是影响进展性肝纤维化发生的5个主要因素。结论医院慢性丙肝患者进展性肝纤维化的发生率较高,应加强丙肝防治知识宣传,提倡慢性丙肝患者早检测和早治疗,并加强对其饮酒等危险行为的干预,以控制进展性肝纤维化的发生。 Objective To find out the incidence of progressive hepatic fibrosis and related influential factors on patients with chronic hepatitis C in hospital.Methods Patients with chronic hepatitis C from 4hospitals in Beijing,Henan,Jilin and Liaoning provinces were surveyed by questionnaires.Results A total of 218 cases,including 171males(47.6%)and 188females(52.4%),were under investigation,with the average age of(55.1±11.9).For218 patients with progressive hepatic fibrosis,the incidence rate was 60.7%.Data from the multivariate logistic regression analysis showed that factors as:age≥40,male,alcohol consumption≥50g/d,not received antiviral treatment,HIV/HBV co-infection were associated with high incidence of progressive hepatic fibrosis.Conclusion This study indicated that the incidence rate of progressive hepatic fibrosis was high.Promoting early treatment,strengthening the knowledge of hepatitis C prevention and intervening drinking behavior may contributed to control the progress of liver fibrosis.
出处 《中国艾滋病性病》 CAS 北大核心 2015年第5期414-417,共4页 Chinese Journal of Aids & STD
关键词 慢性丙型肝炎患者 进展性肝纤维化 影响因素 Patients with chronic hepatitis C Progressive fibrosis Influential factors
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