摘要
目的了解医院慢性丙型病毒性肝炎(简称"丙肝")患者的进展性肝纤维化的发生率和影响因素。方法在北京、河南、吉林、辽宁四个省(直辖市)的4家综合医院中,选取在治的慢性丙肝患者进行问卷调查,内容包括研究对象一般人口学特征、感染途径、行为学特征、治疗情况,并结合病历收集患者的实验室检测等结果。结果共调查慢性丙肝患者359例,其中男性171例(47.6%),女性188例(52.4%),平均年龄(55.1±11.9)岁。有进展性肝纤维化者为218例,发生率为60.7%。多因素Logistic回归分析发现,≥40岁、男性、酒精摄入量≥50克/天、未接受抗病毒治疗、合并感染艾滋病病毒(HIV)/乙型肝炎病毒(HBV),是影响进展性肝纤维化发生的5个主要因素。结论医院慢性丙肝患者进展性肝纤维化的发生率较高,应加强丙肝防治知识宣传,提倡慢性丙肝患者早检测和早治疗,并加强对其饮酒等危险行为的干预,以控制进展性肝纤维化的发生。
Objective To find out the incidence of progressive hepatic fibrosis and related influential factors on patients with chronic hepatitis C in hospital.Methods Patients with chronic hepatitis C from 4hospitals in Beijing,Henan,Jilin and Liaoning provinces were surveyed by questionnaires.Results A total of 218 cases,including 171males(47.6%)and 188females(52.4%),were under investigation,with the average age of(55.1±11.9).For218 patients with progressive hepatic fibrosis,the incidence rate was 60.7%.Data from the multivariate logistic regression analysis showed that factors as:age≥40,male,alcohol consumption≥50g/d,not received antiviral treatment,HIV/HBV co-infection were associated with high incidence of progressive hepatic fibrosis.Conclusion This study indicated that the incidence rate of progressive hepatic fibrosis was high.Promoting early treatment,strengthening the knowledge of hepatitis C prevention and intervening drinking behavior may contributed to control the progress of liver fibrosis.
出处
《中国艾滋病性病》
CAS
北大核心
2015年第5期414-417,共4页
Chinese Journal of Aids & STD
关键词
慢性丙型肝炎患者
进展性肝纤维化
影响因素
Patients with chronic hepatitis C
Progressive fibrosis
Influential factors