摘要
目的探讨硫辛酸对早期糖尿病足患者氧化应激、炎症反应的影响。方法 90例糖尿病足患者随机分成观察组和对照组(均45例),2组常规治疗相同,在此基础上,观察组给予硫辛酸胶囊,1次0.2 g,1日3次,疗程为4周。用硫代巴比妥酸反应法检测超氧化物歧化酶(SOD)和丙二醛(MDA),用酶联免疫吸附法检测血清晚期蛋白氧化产物(AOPPs)、血管细胞黏附分子-1(VCAM-1)、成纤维细胞生长因子2(FGF-2)和肿瘤坏死因子-α(TNF-α),用电化学发光法检测白介素-6(IL-6),并比较2组治疗前和治疗后上述指标的差异。结果观察组有效率(84.44%)显著高于对照组(64.44%)(P<0.05);治疗后,观察组AOPPs、MDA、VCAM-1、FGF2、TNF-α和IL-6均显著低于对照组,而SOD显著高于对照组(均P<0.05)。结论硫辛酸可提高糖尿病足治疗的有效率,改善氧化应激反应和炎症状态。
Objective To explore the effect of alprostadil on oxidative stress and inflammation in patients with diabetic foot.Methods Ninety diabetic foot patients were randomly divided into the observe group （ n=45）and the control group（n =45）.They all accepted the conventional treatment, but the patients in the observed group were given the treatment of alprostadil capsules, 1 time 0.2 g, 3 times a day, for 4 weeks.The concentrations of superoxide dismutase （ SOD ） and malondialdehyde （ MDA） were detected by thiobarbituric acid reaction.The concentrations of advanced oxidation protein products （ AOPPs ） , vascular cell adhesion molecule-1 （ VCAM -1 ） , fibroblast growth factor 2 （ FGF -2 ） and tumor necrosis factor alpha （ TNF -alpha ） were detected by enzyme linked immunosorbent assay.And the concentration of interleukin -6 （ IL-6） was detected by the electrochemical luminescence method.The concentrations of SOD, MDA, AOPPs, VCAM-1, FGF-2, IL-6 and TNF-alpha were compared between the two groups before and after treat-ment.Results The efficiency in the observation group （84.44%） was significantly higher than that in control group （64.44%）.After treatment, the AOPPs, MDA, VCAM -1, FGF2, TNF -alpha and IL-6 in the observation group were significantly lower than that in the control group （ P〈0.05） , and the SOD in the observed group was significantly higher than that in the control group （ P 〈0.05 ）.Conclusion Alprostadil＆amp;nbsp;couldimprove the clinical efficacy by improving oxidative stress and inflammation in diabetic foot patients.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第11期909-911,915,共4页
The Chinese Journal of Clinical Pharmacology
关键词
硫辛酸
糖尿病足
氧化应激
炎症
alprostadil
diabetic foot
oxidative stress
inflammation
