摘要
目的探讨不同剂量依达拉奉用于治疗缺血性脑血管病疗效。方法选择2013年2月—2014年2月该院收治的缺血性脑血管病患者84例,随机分为小剂量和大剂量二组,每组各42例。小剂量组给予60mg/d依达拉奉进行治疗,大剂量组给予120mg/d依达拉奉进行治疗。对二组患者治疗后的神经功能缺损评分、Barthel指数、总有效率及不良反应发生率进行比较。结果 1治疗后小剂量组与大剂量组的神经功能缺损评分均明显低于治疗前,差异具有统计学意义(P<0.05);治疗后小剂量组与大剂量组的神经功能缺损评分相比较,差异无统计学意义(P>0.05)。2治疗后小剂量组与大剂量组的Barthel指数均明显高于治疗前,差异具有统计学意义(P<0.05);治疗后小剂量组与大剂量组的Barthel指数相比较,差异无统计学意义(P>0.05)。3治疗后小剂量组的总有效率(78.6%)与大剂量组(71.4%)相比较,差异无统计学意义(P>0.05)。4治疗后小剂量组的不良反应发生率(4.8%)明显低于大剂量组(26.1%),差异具有统计学意义(P<0.05)。结论对缺血性脑血管病患者,小剂量依达拉奉与大剂量依达拉奉在改善患者神经功能,提高日常活动能力及总有效率方面效果相当,但小剂量依达拉奉治疗所产生的不良反应相对较少,具有较高的安全性,值得临床推广与应用。
Objective To investigate the efficacy of different doses of Edaravone in treatment of ischemic ce- rebrovascular disease. Methods Totally 84 eases of patients with isehemic eerebrovascular disease in au- thor＇s hospital from February 2013 to February 20t4 were randomly divided into two groups, with 42 cases in each group. Low - dose group was treated by Edaravone （60mg/d}, while high- dose group was treated by Edaravone （120mg/d）. Neurological deficit scores, BI scores, total efficiency and the incidence of ad- verse reactions of the two groups were compared. Results Neurological deficit scores of two groups pa- tients after treatment was significantly lower than before treatment, the difference was statistically signifi- cant （P〈0.05）. There were no significant differences in two groups of neurological deficit scores after treatment （P〉0.05）. BI scores of two groups patients after treatment was significantly lower than before treatment, the difference was statistically significant （P〈0.05）. There were no significant differences in two groups of BI scores after treatment （P〉0.05）. There were no significant differences in two groups of total efficiency after treatment （P〉0.05）. The total efficiency of patients in low dose group （4. 8%） was significantly lower than that in high dose group （26.1 G）, the difference was statistically significant （P〈0.05）. Conclusion Low doses of Edaravone in improving neurological function, enhancing activities of dai- ly living and total efficiency is similiar with high doses of Edaravone, but low doses of Edaravone has rela- tively few adverse effects and high safety. It is worthy of clinical application.
出处
《中国煤炭工业医学杂志》
2015年第6期902-904,共3页
Chinese Journal of Coal Industry Medicine
基金
河北省中医药管理局科研计划项目(编号:2014328)
关键词
依达拉奉
缺血性脑血管病
药物治疗
Edaravone
Ischemic eerebrovascular disease
Drug therapy
