摘要
目的探讨无症状颈动脉狭窄与认知功能障碍的关系。方法选取2013年1月至2014年1月收治的100例无症状颈动脉狭窄患者为观察组,另选择同期门诊体检正常者100例为对照组。采用简易智能状态检查量表对两组进行认知功能评分,比较两组的临床资料,分析无症状颈动脉狭窄和认知功能障碍的关系。对比观察组颈动脉支架植入术后1周、1个月、3个月、6个月智能状态检查量表得分。结果观察组认知功能评分明显低于对照组,差异有统计学意义(P<0.05)。观察组患者进行颈动脉支架植入术治疗后1个月、3个月、6个月智能状态检查量表评分分别为:27.3±1.2分,28.5±1.0分,28.9±0.9分,与治疗前比较差异有统计学意义(P<0.05)。无症状颈动脉狭窄治疗后1个月时,患者的认知功能开始改善,治疗后1个月到3个月随着时间的延长认知功能改善越来越明显,而在治疗后3个月到6个月认知功能无明显改善。患者的连线测试、顺背测试评分、词汇测试得分降低(P<0.05)。结论无症状颈动脉狭窄引发患者认知障碍,主要损害患者的认知转换、执行功能和注意功能。
Objective To observe the relationship between asymptomatic carotid artery stenosis and the cognitive dysfunction. Methods 100 cases of phlebitis were selected from 2013 January to 2014 January. 100 cases were selected as control group at the same period selection out-patient medical. The cognitive function were scored in the two groups by simple intelligent state examination scale. The clinical data of the group and the control group were compared. The relationship between asymptomatic carotid artery stenosis and the cognitive dysfunction were analyzed by SPSS14. 0. Results Compared with before treatment,patients in study group treated with carotid endarterectomy for the treatment after 1 months, 3 months,6 months of mental. The state examination scores were：27. 3 ± 1. 2,28. 5 ± 1. 0,28. 9 ± 0. 9,the difference was statistically signifi-cant compared with before treatment（ P 〈0. 05）. The cognitive function began to improve in asymptomatic carotid stenosis 1 month after treat-ment. The cognitive function improve with the extension of time 1 month to 3 months after treatment. The cognitive function did not show improving after treatment for 3 months and 6 months. Along the back test score,attachment test,vocabulary test score lower scores. The differences were sta-tistically significant（ P 〈0. 05）. Conclusion The asymptomatic carotid stenosis can cause cognitive disorders,including major damage in pa-tients with cognitive transformation,executive function and paying attention to the function.
出处
《临床和实验医学杂志》
2015年第11期879-881,共3页
Journal of Clinical and Experimental Medicine
基金
国家杰出青年科学基金资助项目(项目编号:0602150028)
关键词
无症状颈动脉狭窄
认知障碍
Asymptomatic Carotid stenosis
Cognitive impairment
