摘要
肠易激综合征(irritable bowel syndrome,IBS)是常见的功能性胃肠疾病,其发病率、复发率高,严重影响患者的生活质量,对社会医疗资源和家庭经济造成极大负担.多数学者认为压力、感染、食物过敏等可通过神经-免疫-内分泌系统介导IBS的发生,并一直将其作为功能性疾病加以研究.腹痛为IBS典型表现,与内脏高敏密切相关.近些年随着IBS"低度炎症状态"的提出,IBS发生的相关免疫机制成为研究热点.肥大细胞(mast cell,MC)为肠道重要的免疫细胞,其数目的改变,活化脱颗粒效应以及与感觉神经的相互作用在IBS的发生中起着重要作用.本文将主要就MC与IBS发病的关系作一综述.
Irritable bowel syndrome（IBS） is a common functional gastrointestinal disorder characterized by high prevalence and recurrence rates, which contribute to the patient＇s poor quality of life and an economic burden to the society and family for substantial costs. Multiple factors（e.g., stress, infection, and food allergy） can induce IBS via the neuro-endocrine-immune system. Abdominal pain, a hallmark symptom of IBS, correlates with visceral hypersensitivity.In recent years, the immune-associated mechanism for IBS has received more and more attention. Mast cells（MCs） are important immune cells in the intestine. The changes in the number, degranulation and interaction of MCs with the nerve play an important role in the development of IBS. This paper reviews the association between mast cells and the onset of IBS.
出处
《世界华人消化杂志》
CAS
2015年第14期2239-2244,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81473644
北京市医院管理局重点医学专业发展计划基金资助项目
No.ZYLX201411~~
关键词
肠易激综合征
肥大细胞
脱颗粒
感觉神经
Irritable bowel syndrome
Mast cells
Degranulation
Sensory neuron
