摘要
目的了解加巴喷丁用于治疗深Ⅱ度烧伤后瘢痕瘙痒的临床疗效。方法选择2013年1月-2014年1月笔者单位收治的58例深Ⅱ度烧伤后瘢痕瘙痒患者，按照随机数字表法分为安慰剂组18例、西替利嗪组20例及加巴喷丁组20例。安慰剂组患者口服维生素C100mg，西替利嗪组患者口服西替利嗪10mg，加巴喷丁组患者口服加巴喷丁300mg，各组患者均用药2次／d，连续服用4周。分别于治疗前及治疗第3、28天应用视觉模拟评分（VAS）法评价患者瘢痕瘙痒程度并记录分值，计算治疗第3、28天瘙痒缓解率，并观察用药过程中有无不良反应。对数据行方差分析、q检验、X2检验。结果与治疗前比较，治疗后安慰剂组轻、中、重度瘙痒患者的瘙痒程度均未缓解；西替利嗪组中、重度瘙痒患者的瘙痒程度均有所缓解，而轻度瘙痒患者未见缓解；加巴喷丁组轻、中、重度瘙痒患者的瘙痒程度均获得明显缓解。治疗前，3组患者的VAS评分相近（F=2．78，P〉0．05）。治疗第3、28天，加巴喷丁组患者的VAS评分分别为（2．3±0．8）、（0．6±0．3）分，西替利嗪组患者VAS评分分别为（4．2±1．7）、（2．8±1．2）分，均显著低于安慰剂组[（5．7±2．0）、（5．7±1．9）分，q值为6．70—7．75，P值均小于0．05]；此外，加巴喷丁组患者的VAS评分均显著低于西替利嗪组（q值分别为6．30、6．90，P值均小于0．05）。加巴喷丁组患者治疗第3、28天的瘙痒缓解率分别为（66±20）％、（91±17）％，均显著高于西替利嗪组[（33±8）％、（56±14）％，q值分别为4．70、3．82，P值均小于0．05]。安慰剂组患者治疗第3、28天的瘙痒缓解率均为0，均显著低于其余2组（q值为3．94～6．76，P值均小于0．05）。治疗期间，加巴喷丁组5例患者出现轻中度嗜睡、头晕等不良反应，用药1周后症状好转或消失；其余2组患者未�
Objective To study the clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn. Methods A total of fifty-eight patients suffering from pruritus of scar after deep partial-thickness burn were hospitalized from January 2013 to January 2014. Patients were divided into placebo group （ n = 18, treated with oral vitamin C in the dose of 100 mg for 4 weeks, twice per day）, cetirizine group （ n =20, treated with oral cetirizine in the dose of 10 mg for 4 weeks, twice per day）, and gabapentin group （ n = 20, treated with oral gabapentin in the dose of 300 mg for 4 weeks, twice per day）. Before treatment and on post treatment day （PTD） 3 and 28, the Visual Analog Scale （VAS） was used to assess the itching degree, and the mean scores were recorded. The remission rates of pruritus on PTD 3 and 28 were calculated. The adverse effects were observed during treatment. Data were processed with analysis of variance, q test, and chi-square test. Results Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment ; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated af- ter treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was sig- nificantly relieved after treatment. There were no obvious differences in VAS scores among the 3 groups be- fore treatment （ F = 2.78, P 〉 0.05）. On PTD 3 and 28, the VAS scores of patients in both gabapentin group [ （2.3 ± 0.8 ） and （0.6 ± 0.3 ） points ] and cetirizine group [ （4.2 ± 1.7） and （2.8 ± 1.2） points ] were lower than those in placebo group [ （5.7 ± 2.0） and （5.7 ± 1.9） points, with q values from 6.70 to 7.75, P values below 0.05 ]. The VAS scores of patients in gabapentin group on PTD 3 and 28 were lower than those in cetirizine group （with q values respectively 6.30 and 6.90, P values be
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2015年第3期177-180,共4页
Chinese Journal of Burns
