摘要
目的：探讨孟鲁司特咀嚼片提高儿童咳嗽变异性哮喘治疗有效率。方法：选择咳嗽变异性哮喘患儿105例,随机分为常规治疗组56例及孟鲁司特治疗组49例,其中常规治疗组接受长期糖皮质激素吸入和短期β2受体激动剂口服以及抗过敏、祛痰止咳等对症治疗。孟鲁司特治疗组在常规治疗的基础上口服孟鲁司特咀嚼片,每次4-5 mg,每日睡前1次,3个月后剂量减半,共持续6个月。比较2组患儿治疗后2周、6个月的疗效。结果：治疗后2周,孟鲁司特治疗组的总有效率为71.43%,高于常规治疗组的50.00%（P〈0.01）;治疗后6个月,孟鲁司特治疗组的总有效率高达91.84%,高于常规治疗组的69.64%（P〈0.01）,且在整个治疗过程中未观察到明显不良反应。结论：无论短期还是长期口服孟鲁司特咀嚼片对于儿童咳嗽变异性哮喘均可明显提高有效率,且长期治疗效果更佳。
Objective：To explore the clinical effects of Montelukast in the treatment of cough-variant asthma in children. Methods： One hundred and five children with cough-variant asthma were randomly divided into the routine treatment group （56 cases ） and Montelukast treatment group（49 cases）. The routine treatment group were treated with inhaled corticosteroids for a long time ,oral beta 2 receptor agonists for a short time combined with antiallergy, antitussive and expectotating phlegm, the Montelukast treatment group were treated with Montelukast （ 4 to 5 mg each time, once a day, by half after 3 months for 6 months） based on the routine treatment. The effects between two groups were compared after 2 weeks and 6 months of treatment. Results： After 2 weeks of treatment, the effective rate in M ontelukast treatment group （71.43 % ） was higher than that in routine treatment group （50.00%） （P 〈 0.01 ）. After 6 months of treatment, the effective rate in Montelukast treatment group were 91.84% , which was significantly higher than that in routine treatment group（69.64% ）（ P 〈 0.01 ）, and no obvious adverse reaction was observed in Montelukast treatment group. Conclusions： Whether short-term or long-term oral treatment, Montelukast can obviously improve the treatment effects of cough-variant asthma in children, especial for the long-term treatment.
出处
《蚌埠医学院学报》
CAS
2015年第5期622-623,626,共3页
Journal of Bengbu Medical College
