摘要
目的探讨尿肾损伤分子-1(Kim-1)检测在急性肾损伤(AKI)诊断中的价值。方法选择确诊的AKI患者71例作为AKI组,并选择同时期健康体检者30例为健康对照组,分别检测尿Kim-1及血肌酐(Scr)水平。结果 AKI组Scr、尿Kim-1较健康对照组明显升高(P<0.01),与健康对照组比较,Scr、尿Kim-1在AKI 1期、2期、3期均明显升高(P<0.01),与AKI 1期比较,Scr、尿Kim-1在AKI 2期、3期均明显升高(P<0.01),与AKI 2期比较,Scr及尿Kim-1在AKI 3期均明显升高(P<0.01);尿Kim-1与Scr之间具有明显相关性(r=0.842,P<0.01);尿Kim-1 ROC曲线下面积为0.915。结论尿Kim-1在AKI患者中排泄升高,对AKI具有诊断价值,可能为诊断AKI的敏感指标。
Objective To explore the diagnostic value of urinary Kidney injury molecule-1 （Kim-1）detec-tion in patients with acute kidney injury （AKI）.Method Seventy-one patients with AKI were selected as the study group （AKI group）,and 30 healthy individuals were enrolled as the control group.The levels of urinary Kim-1 and serum creatinine （Scr）were measured respectively.Results The urinary Kim-1 and Scr were increased significantly （P 〈0.01）in AKI group when compared with the control group.The urinary Kim-1 and Scr increased significantly （P 〈0.01）in AKI stage 1,2 and 3 in AKI group when compared with control group.The urinary Kim-1 and Scr were increased significantly （P 〈0.01）in AKI stage 2 and 3 when compared with stage 1.The urinary Kim-1 and Scr were increased significantly （P 〈0.01）in AKI stage 3 when compared with AKI stage 2.There was significant relationship between the urinary Kim-1 and Scr.The area under the receiver operating characteristics curve in the uri-nary Kim-1 was 0.915.Conclusion The urinary Kim-1 excretion increases significantly in AKI group.It maybe has diagnostic value in AKI and used as a sensitive target diagnostic criteria for AKI.
出处
《中国临床保健杂志》
CAS
2015年第3期249-251,共3页
Chinese Journal of Clinical Healthcare
基金
安徽省科技计划项目(10021403082)
关键词
急性肾损伤
诊断技术
泌尿科
糖蛋白类
Acute kidney injury
Diagnostic techniques,urological
Glycoproteins
