摘要
目的:评价多种整治措施对我院2011-2013年特殊使用级抗菌药物临床应用的影响,为合理使用抗菌药物提供参考。方法:对我院2011-2013年特殊使用级抗菌药物的销售金额、用药频度(DDDs)、日均费用(DDC)、抗菌药物使用强度(AUD)等指标进行回顾性统计分析。结果:3年间我院特殊使用级抗菌药物的各项指标均明显改善:特殊使用级抗菌药物的销售金额比例从2.29%下降至1.58%;总品规数从13个减少至7个,品规结构也得到了优化;总DDDs从14 440.19下降至7 339.21;总AUD从3.181 DDDs/(100人·d)下降至1.331 DDDs/(100人·d)。由各类特殊使用级抗菌药物的DDDs、销售金额的构成比可见,我院临床最常用的特殊使用级抗菌药物从β-内酰胺+酶抑制剂类变更为碳青霉烯类,且解决了过于集中使用某种抗菌药物的问题。各个特殊使用级抗菌药物的DDDs、销售金额及DDC排序与用药人数的同步性越来越好,且在新医改方案执行后我院的特殊使用级抗菌药物的DDC在逐年下降。结论:我院在实施了制度层面和技术层面的有效管理、品规结构优化以及抗菌特点宣教等措施后,特殊使用级抗菌药物的临床管理和使用状况得到改善,但仍需进行可持续的管理以避免出现反弹。
OBJECTIVE： To evaluate the effects of various measures on clinical use of antibacterial drags for special use in our hospital from 2011 to 2013 and provide reference for the rational use of antibacterial drugs. METHODS： The utilization of antibacterial drugs for special use in our hospital from 2011 to 2013 was analyzed statistically in respect of the consumption sum, DDDs, DDC and AUD, etc. RESULTS： The indicators of antibacterial drugs for special use in our hospital were obviously improved in 3 years; the consumption sum proportion of antibacterial drugs for special use dropped from 2.29% to 1.58%; the total number of specifications reduced from 13 to 7, and specifications structure was also optimized; the total DDDs reduced from 14 440.19 to 7 339.21; the total AUD dropped from 3.181 DDDs/（100 persons.d） to 1.331 DDDs/（100 persons.d）. From the constitu- ent ratio of DDDs and consumption sum, commonly used antibacterial drugs for special use in our hospital was carbapenems in- stead of β-Lactam/enzyme inhibitor, and it solved the phenomenon of concentrate use of antibacterial drugs. DDDs, consumption sum and DDC sorting of antibacterial drugs for special use more and more stayed in step with the number of patients. After the implementation of New Medical Reform, DDC of antibacterial drugs for special use declined year by year. CONCLUSIONS ： After the implementation of the system level and technical level of effective management, specification structure optimization and antibacterial characteristics education, the clinical management and use of antibacterial drugs for special use have been improved in our hospital, but would still need a sustainable management in order to avoid a rebound.
出处
《中国药房》
CAS
北大核心
2015年第17期2330-2334,共5页
China Pharmacy
