摘要
目的研究门冬胰岛素30单用或联合其他降血糖药物治疗2型糖尿病时对患者血糖波动的影响。方法 94例2型糖尿病患者随机分为三组。A组31例,单用门冬胰岛素30,早晚餐前皮下注射,起始剂量0.4 U·kg-1·d-1。B组32例,门冬胰岛素30(用法同前)+瑞格列奈1.0 mg,po,tid。C组31例,门冬胰岛素30(用法同前)+阿卡波糖50 mg,po,tid。记录各组血糖达标时间及达标后日均胰岛素用量,采用全日7点血糖(三餐前、餐后2 h、晚上23:00)监测法来评价三组患者血糖波动情况,并观察低血糖发生情况。结果 A组达标时间长于B组和C组,达标后日均胰岛素用量高于其他两组,均有显著差异(P<0.05),B组和C组达标时间、达标后日均胰岛素用量均无显著差异(P>0.05)。三组治疗后全日7点血糖、平均血糖值、血糖标准差(SDBG)均降低(P<0.05)。A组中餐后血糖、血糖漂移值及SDBG高于B组和C组(P<0.05),B组高于C组(P<0.05)。C组早、晚餐后血糖漂移值低于A组和B组(P<0.05),A、B两组间无显著差异(P>0.05)。C组低血糖发生率10%,低于A组(39%)和B组(25%),差异显著(P<0.05),A、B两组间无显著差异(P>0.05)。结论三种治疗方案均能有效改善2型糖尿病患者血糖,门冬胰岛素30联合阿卡波糖在降低餐后血糖漂移、SDBG及低血糖发生率方面优于门冬胰岛素30单用及与瑞格列奈联用方案。
AIM To study the effects of insulin aspart 30 alone or combined with other hypoglycemic agents on the blood glucose fluctuation in type 2 diabetes patients. METHODS Ninety-four type 2 diabetes patients were randomly divided into three groups. Group A（ n = 31） ： insulin aspart 30 injection was administrated before breakfast and dinner, with the initial dose 0.4 U·kg-1·d-1; group B（ n = 32） ： insulin aspart 30 injection was used as group A, and together with repaglinide（1.0 mg, po, tid）; group C（n = 31）：insulin aspart 30 injection was used as group A, and together with acarbose（ 50 mg, po, tid）. The time to reach well-controlled blood glucose and daily insulin dosage were recorded. The 7 point（before meals, 2 hours after meals and 23： 00 p.m.） blood glucose monitoring method was used to evaluate the blood glucose fluctuations and the incidence of hypoglycemia was observed. RESULTS The time and daily insulin dose used to achieve well-controlled the blood glucose were significantly higher in the group A than those of the group B and group C（ P 〈 0.05）, while no significant difference between group B and group C（ P 〉 0.05）. After the treatment, the 7 point blood glucose throughout the day, mean and standard deviation of blood glucose（MBG and SDBG） of all three groups decreased significantly（P 〈 0.05）. The blood glucose after lunch, fluctuation of postprandial blood glucose（PBG） after lunch and SDBG of group A were significantly higher than those of the group B and group C（ P 〈 0.05）, and those in the group B were higher than the group C（ P 〈 0.05）. The fluctuation of PBG after breakfast and dinner of the group C were lower than those of the group A and group B（P 〈 0.05）, while no significant between group A and group B（P 〉 0.05）. The incidence rate of hypoglycemia of the group C was 10%, which was significantly lower than that in the group A（39%） and B（25%, P 〈0.05）, while no significant difference between group A and group B
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2015年第5期386-389,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
糖尿病
2型
门冬胰岛素
阿卡波糖
瑞格列奈
血糖波动
diabetes mellitus,type 2
insulin aspart
acarbose
repaglinide
blood glucose fluctuation
