摘要
目的了解影响老年癫痫患者丙戊酸钠血药浓度的因素,为临床用药提供科学依据,促进丙戊酸钠的合理使用。方法采用荧光偏振免疫法测定丙戊酸钠血药浓度,并对某三甲医院老年癫痫患者丙戊酸钠血药浓度监测结果进行回顾性分析。结果 60岁及以上的老年患者共计295例次,其中男152例次,女143例次;男性、女性丙戊酸钠血药浓度无差异;随着年龄的增高,丙戊酸钠血药浓度在治疗窗内的构成比逐渐降低,80岁以上组与60∽69岁组相比丙戊酸钠血药浓度降低（P〈0.05）;丙戊酸钠合并酶诱导类抗癫痫剂组或碳青霉烯类抗生素组与单用丙戊酸钠组相比,丙戊酸钠血药浓度降低（P〈0.05）。结论丙戊酸钠血药浓度影响因素复杂,应对老年人尤其是高龄人群进行丙戊酸钠血药浓度监测,结合临床疗效,进行个体化给药。
OBJECTIVE To know the correlatively influencing factors on the serum concentration of valproic acid sodium （VPA） in elderly patients with epilepsy, and provide reference on clinical safety and rational use. METHODS The serum concentration of VPA was monitored by fluorescence polarization immunoassay （FPIA）, and a retrospective analysis was made on the distribution of blood concentration and therapeutic effect. RESULTS In the 295 cases of the elderly patients（ ≥60 years） ,there were 152 cases in male and 143 cases in female, and no significant difference was found between genders. The serum concentration of VPA within the therapeutic window of percentage had a tendency of decrease with aging, but the serum concentration of VPA in the group of 80 years and elder was lower than the group of 60 - 69 years （ P 〈 0. 05 ）. The serum concentration of VPA in the groups of drug combination were lower than the group of VPA alone. CONCLUSION The influencing factors on the serum concentration of VPA are complicated, it is of great importance to monitor the serum VPA concentration and formulate individual dosage in elderly people so as to ensure clinical efficacy and reduce risk of toxic ,reaction.
出处
《海峡药学》
2015年第5期247-249,共3页
Strait Pharmaceutical Journal
关键词
丙戊酸钠
血药浓度
老年癫痫患者
Valproic acid sodium
Serum concentration
Elderly patients with epilepsy
