摘要
目的观察血必净注射液对毛细血管渗漏综合征(CLS)患者血管内皮细胞的保护作用及临床疗效。方法将CLS患者59例随机分为对照组和血必净组,在相同的常规治疗基础上,血必净组加用血必净注射液100ml静脉滴注。选择健康查体者30例作为正常组,两组患者均在入院时及治疗第2、5、7天检测外周血循环内皮细胞(CEC)及尿微量白蛋白(MAU)。结果 1入院时两组患者CEC和MAU均高于正常组(P<0.01)。血必净组和对照组在治疗第2、5、7天CEC、MAU含量逐渐下降(P<0.05或<0.01);2血必净组治疗后第7天急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)评分、多器官功能障碍综合征(MODS)发生率和28天病死率均显著低于对照组(均P<0.01);3MAU与CEC、APACHEⅡ评分、MODS发生率及28天病死率均呈正相关(均P<0.01)。结论血必净注射液对CLS患者血管内皮细胞有保护作用,有良好的临床疗效。MAU是早期反映CLS患者血管内皮损伤和病情严重程度的良好指标。
Objective To observe the protective effect on vascular endothelium and clinical efficacy of Xuebijing in patients with capillary leak syndrome（CLS）.Methods A total of 59 CLS patients were divided randomly into two groups：control group and Xuebijing group.Both groups received routine treatment.In Xuebijing group,patients were treated with intravenous Xuebijing injection 100 ml,q 12 h,for 7 days.Normal group included 30 healthy controls of outpatients at corresponding period.Circulating endothelial cell （CEC）and microalbuminuria （MAU）were measured in all patients on admission to hospital and on the 2nd,5th,7th days,respectively.Results ① CEC and MAU were markedly higher in both groups than in normal group on admission to hospital （P 〈 0.01 ）.CEC and MAU in Xuebijing group and control group decreased gradually on the 2nd,5th and 7th day,with statistically significant differences （P 〈0.05 and P 〈0.01,respectively）.② APACHEⅡscores,incidence of MODS and 28 d fatality rate in Xuebijing group were significantly lower than those of control group on the 7th day（P 〈0.01）.③ Correlation analysis showed that CEC,APACHEⅡ scores,incidence of MODS and 28 d fatality rate were positively correlated with MAU （P 〈0.01）.Conclusion Xuebijing has a protective effect on vascular endothelium in patients with CLS,and good clinical efficacy.MAU may be an early and good indicator for vascular endothelial injury and disease severity in patients with CLS.
出处
《临床荟萃》
CAS
2015年第6期660-663,共4页
Clinical Focus
