摘要
目的 探讨氧驱雾化吸入噻托溴铵联合盐酸氨溴索治疗老年COPD急性加重期的临床疗效。方法筛选2013年1月至2014年6月我院收治的老年COPD急性加重期患者184例作为研究对象。所有患者均确诊COPD急性加重期，采用随机数表法将其分为对照组、治疗组A、治疗组B与联合组，每组46例，其中对照组患者入院后根据患者病情进行相应的抗炎、化痰、止喘、糖皮质激素治疗，治疗组A在此基础上采用盐酸氨溴索氧驱雾化吸入治疗，治疗组B患者采取噻托溴铵粉雾氧驱雾化吸入，联合组患者采取氧驱雾化吸入噻托溴铵联合盐酸氨溴索治疗方案，治疗组A、B与联合组患者根据病情每日雾化治疗2～3次，单次雾化15min，共持续性治疗7d。采集治疗前后各组患者动脉血气分析结果及肺功能评分指标，并比较4组患者治疗有效率。结果对照组、治疗组A、B与联合组患者治疗后动脉血气分析PaO2、PaCO2指标均较治疗前改善（P〈0．05），但治疗组A、B与联合组改善明显较对照组具有优势，并且联合组改善效果更为显著，差异有统计学意义（P〈0．05）；肺功能测定可知4组患者治疗后均有改善，同时治疗组A、B与联合组患者改善效果明显优于对照组，且以联合组改善最为显著；治疗总有效率比较中，联合组治疗总有效率明显高于对照组、治疗组A与治疗组B，差异有统计学意义（P〈0．05）。结论氧驱雾化吸入噻托溴铵联合盐酸氨溴索治疗方法可提升老年cOPD急性加重期患者的临床治疗效果，氧驱雾化设备能够使药物液滴与终末细支气管、呼吸小叶结合更充分，并且噻托溴铵联合盐酸氨溴索可达到协同作用目的，能够快速改善COPD急性加重期患者的临床症状与表现，具有临床应用及推广价值。
Objective To investigate the clinical efficacy of oxygen nebulizer inhalation of tiotropium bromide combined with ambroxol hydrochloride in treatment of elderly patients with acuteaggravating period COPD. Methods In 2013 January to aggravated stage COPD patients with 184 cases as the 2014 June were treated in our hospital senile acute research object. All patients were diagnosed with acute exacerbation of COPD, were randomly divided into the control group, the treatment group A, treatment group B and the combined group, 46 cases in each group, the control group of patients after admission in patients of phlegm, anti inflammation, relieving asthma, glucocorticoid A treatment, treatment group on the basis of oxygen atomized inhalation of ambroxol hydrochloride in treatment of B patients, the treatment group took tiotropium bromide powder combined with oxygen nebulizer inhalation, patients taking oxygen atomization inhalation of tiotropium bromide combined with hydrochloric acid ammonia bromine Suozhi therapy,the treatment group A, B and joint groups of patients according to the condition of daily inhalation in the treatment of 2-3, min a total of 15 single atomization, eontinuouslv for 7 d. Arterial blood gas analysis index and lung function were measured before and after treatment in patients with dynamic acquisition, and compared between the two groups of patients treatment efficiency. Results In the control group, treatment group A, B and the joint group of patients after treatment of arterial blood gas analysis of PaO2 ,PaCO2 were improved compared with before treatment （ P 〈0.05）, but the treatment group A,B and combination group is obviously higher than that of Gai Shanming has the advantage of the control group, and combined group improved more significantly, the difference was statistically statistical significance （ P 〈 0.05） pulmonary function were improved measuring about 4 groups of patients after treatment, and treatment group A, B and the joint group patients improved significantly better
出处
《国际呼吸杂志》
2015年第11期815-818,共4页
International Journal of Respiration
关键词
氧驱雾化吸入
噻托溴铵
盐酸氨溴索
老年COPD急性加重期
临床疗效
Oxygen atomization inhalation
Tiotropium Ambroxol hydroehloride
Elderly acuteexacerbation of COPD Clinieal effect
