摘要
目的:对比分析拉莫三嗪和卡马西平对老年人原发性癫痫的治疗效果。方法:选取2012年4月-2014年4月期间确诊为老年人原发性癫痫患者96例,随机分成两组,分别给予卡马西平和拉莫三嗪治疗,观察干预后发作情况,以发作减少频率为监测指标比较药物有效率,以卡马西平组与拉莫三嗪组药物治疗后不良反应发生率及严重程度判断两者的安全性。结果:卡马西平组总有效率68.0%(34/50),拉莫三嗪组总有效率为87.0%(40/46),两组差异具有统计学意义(P=0.031)。卡马西平组不良反应的发生率为38.0%,拉莫三嗪组的不良反应发生率为19.6%,两组间比较有统计学差异(P=0.047)。结论:拉莫三嗪对治疗老年人原发性癫痫的疗效优于卡马西平,且拉莫三嗪的用药安全性比卡马西平高,拉莫三嗪更适用于老年人原发性癫痫的治疗。
Objective：To compare the therapeutic effects of lamotrigine and carbamazepine in the treatment of elderly patients with primary epilepsy.Methods：About 96 elderly patients with primary epilepsy who were diag-nosed during April 2012 to April 2014 were divided randomly into two groups and given carbamazepine and lamot-rigine respectively for treatment. Observation was conducted on the seizure control and the drug effective rate was monitored and compared by the frequency of seizures,and safety was observed of the two groups on the incidence of adverse drug reactions and severity.Results：The total efficiency in carbamazepine group was 68.0%（34/50） and 87.0%（40/46）in lamotrigine group（P= 0.031）,and there was a significant difference between the two groups. The incidence rate of adverse reactions was 38.0% and 19.6% in carbamazepine and lamotrigine groups respectively（P= 0.047）,and there was a statistical difference between the two groups.Conclusion：Better thera-peutic effect and drug safety of lamotrigine were showed in the treatment of elderly patients with primary epilepsy compared with that of carbamazepine. Therefore lamotrigine is more suitable for the treatment of elderly patients with primary epilepsy.
出处
《中国执业药师》
CAS
2015年第6期3-6,16,共5页
China Licensed Pharmacist
关键词
卡马西平
拉莫三嗪
老年人
原发性癫痫
疗效分析
Carbamazepine
Lamotrigine
Elderly
Primary Epilepsy
Therapeutic Effect Analysis
