摘要
川芎具有广泛的临床应用,是常用中药之一,但其有效物质及作用机制尚不明确。该研究优选川芎治疗脑缺血的有效成分,并探究其作用机制。选取4个与脑缺血相关的靶蛋白,以对应的上市药物为参照,基于分子对接技术对文献报道的川芎所含45种成分进行联合筛选。结果显示川芎中多个成分与靶点的对接结果优于对应的上市药物,如苯酞类物质,提示可能是川芎治疗脑缺血的主要有效成分。该方法可用于研究中药的物质基础和分子作用机制。
To explore the effective ingredients and mechanism of Ligusticum wallichii in treating brain ischemia. Four brain ischemia-related target proteins were selected in the joint screening for the 45 component in L. wallichii reported in literatures based on molecular docking by reference to the corresponding drugs in the market. According to the docking results, multiple components in L. wallichii, such as phthalides, were superior to the corresponding drugs in the market, suggesting that they may be the major effective components in L. wallichii for treating brain ischemia. The method can be used to study the material base and molecular mechanism of traditional Chinese medicines.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第11期2195-2198,共4页
China Journal of Chinese Materia Medica
关键词
川芎
分子对接
脑缺血
Ligusticum wallichii
molecular docking
brain ischemia
