摘要
目的观察慢性阻塞性肺疾病(COPD)合并外周骨骼肌功能障碍(PSMD)患者炎性因子白细胞介素(IL)-6、IL-8和IL-10水平、代谢指标及线粒体功能的变化。方法选择2012年7月至2013年7月在泸州市人民医院接受治疗的COPD患者86例作为研究对象,根据是否合并PSMD分为COPD合并PSMD组43例和COPD组43例,另选择健康人43例作为对照组,检测并对比各组受试者炎症细胞因子水平、代谢指标水平及线粒体功能。结果COPD合并PSMD组和COPD组患者血清IL-6、IL-8水平显著高于对照组(P<0.05),但IL-10水平显著低于对照组(P<0.05);COPD合并PSMD组患者血清IL-6、IL-8水平显著高于COPD组(P<0.05),但IL-10水平显著低于COPD组(P<0.05)。COPD合并PSMD组和COPD组患者空腹胰岛素(FINS)、瘦素(LP)水平显著高于对照组(P<0.05),而胰岛素样生长因子-1(IGF-1)水平显著低于对照组(P<0.05);COPD合并PSMD组患者FINS、LP水平显著高于COPD组(P<0.05),而IGF-1水平低于COPD组(P<0.05)。COPD合并PSMD组和COPD组患者线粒体Ⅲ态呼吸速率(ST3)、Ⅳ态呼吸速率(ST4)、呼吸控制率(RCR)、线粒体DNA(mt DNA)表达水平均显著低于对照组(P<0.05),COPD合并PSMD组患者ST3、ST4、RCR及mt DNA表达水平均显著低于COPD组(P<0.05)。线粒体功能与mt DNA表达水平呈正相关(r=0.825,P<0.05)。结论 COPD患者合并PSMD与机体的炎症作用及代谢异常有紧密联系,PSMD的发生机制与线粒体的功能有一定关系。
Objective To observe the changes of inflammatory factor, metaboilic level and mitochondrial function in pa- tients with chronic obstructive pulmonary disease （COPD） complicated with peripheral skeletal muscle dysfunction （PSMD）. Methods Eighty-six patients with COPD in the People＇s Hospital of Luzhou City were selected from July 2012 to July 2013. The patients were divided into COPD ＋ PSMD group （n = 43 ） and COPD group （n = 43 ） according to whether the patients com- plicated with PSMD. Forty-three healthy subjects were selected as control group. The inflammatory level, metaboilic level and mitochondrial function were detected and compared in the groups. Results The levels of serum interleukin（ IL）-6 and 1L-8 in COPD ＋ PSMD group and COPD group were significantly higher than those in control group（ P 〈 0.05 ）. The level of sermn IL- l0 in COPD ＋ PSMD group and COPD group was significantly lower than that in control group（ P 〈 0.05 ）. The levels of serum IL-6 and IL-8 in COPD ＋ PSMD group were significantly higher than those in COPD group（P 〈0.05）. The level of serum IL- 10 in COPD ＋ PSMD group was significantly lower than that in COPD group（ P 〈 0.05 ）. The levels of fasting insulin（FINS） and leptin（LP） in COPD ＋ PSMD group and COPD group were significantly higher than those in control group（ P 〈0.05 ）. The level of insulin-like growth factor-1 （IGF-1） in COPD ＋ PSMD group and COPD group was significantly lower than that in con- trol group（P 〈 0.05 ）. The levels of FINS and LP in COPD ＋ PSMD group were significantly higher than those in COPD group （P 〈 0.05 ）. The level of IGF-1 in COPD ＋ PSMD group was significantly lower than that in COPD group（ P 〈 0. 05）. The Ⅲ state respiration rate of mitochondria （ ST3 ）, IV state respiration rate of mitochondria （ ST4 ）, respiratory control ratio （RCR） and mitochondrial DNA（mtDNA） expression in COPD ＋ PSMD group and COPD group were significantly lower t
出处
《新乡医学院学报》
CAS
2015年第5期412-414,418,共4页
Journal of Xinxiang Medical University
基金
泸州市科技计划项目[编号:2014-S-48(4/6)]
关键词
外周骨骼肌功能障碍
慢性阻塞性肺疾病
炎性因子
代谢水平
线粒体功能
peripheral skeletal muscle dysfunction
chronic obstructive lung disease
inflammatory factor
metaboiliclevel
mitochondrial function
