摘要
目的通过研究1型糖尿病儿童肾叶间动脉血流动力学指标参数的变化,探讨彩色多普勒超声检查对糖尿病肾病潜伏期的临床应用价值。资料与方法选取1型糖尿病儿童52例及健康对照组51例进行肾脏彩色多普勒超声检查,测量肾叶间动脉的阻力指数(RI),并对其临床资料及实验室指标进行比较。结果糖尿病组左肾RI、右肾RI及双肾平均RI均较对照组明显增高,差异有统计学意义(P<0.01)。糖尿病组平均RI与糖化血红蛋白呈正相关(r=0.96,P<0.01),与糖尿病持续时间亦呈正相关(r=0.31,P<0.01)。糖尿病组空腹血糖、糖化血红蛋白、肾小球滤过率均明显高于对照组,差异有统计学意义(P<0.01)。结论 1型糖尿病患儿肾叶间动脉RI指数增高,彩色多普勒超声检查能提示肾脏血流动力学改变情况,对早期糖尿病肾病诊断具有一定的价值。
Purpose To study the hemodynamic changes of kidney interlobar artery in children with type 1 diabetes, and to explore the clinical value of the color Doppler ultrasound in diabetic nephropathy during the incubation period. Materials and Methods The study was performed in 52 children with type 1 diabetes and in 51 age-matched healthy children as control group. The resistance index （RI） of interlobar artery was measured with color Doppler ultrasonography, and the clinical data and laboratory indicators were analyzed. Results The left kidney RI, right kidney RI and average RI were all significantly higher in children with diabetes than in age-matched healthy group （P〈0.01）. The mean RI were correlated positively with （HbA1c） （r=0.96, P〈0.01） and diabetes duration （r=0.31, P〈0.01）, respectively. Fasting blood glucose, glycated hemoglobin, and glomerular filtration rate were significantly higher in children with diabetes than in age-matched healthy group （P〈0.01）. Conclusion The RI of interlobar artery increases in children with type 1 diabetes. Early changes of renal hemodynamics in children with type 1 diabetes are detectable with Doppler sonography, and have certain value in early diagnosis of diabetic nephropathy.
出处
《中国医学影像学杂志》
CSCD
北大核心
2015年第4期273-276,共4页
Chinese Journal of Medical Imaging
关键词
糖尿病
1型
超声检查
多普勒
彩色
肾动脉
血流动力学
糖尿病肾病
儿童
Diabetes mellitus, type 1
Ultrasonography, Doppler, color
Renal artery：Hemodynamics
Diabetic nephropathies
Child
