摘要
Ghrelin是1999年首次发现的一种包含28个氨基酸的脑肠肽,为生长激素促分泌素受体的内源性配体,具有促进生长激素释放、增加进食、促进胃酸分泌、调节胃肠道运动、调节血糖、肝脏保护等多种功能。越来越多的研究发现,Ghrelin水平在肝脏疾病中发生改变,Ghrelin可能通过改善炎症反应、降低氧化应激及细胞凋亡、抗纤维化等多种途径发挥肝脏保护作用。Ghrelin与肝脏疾病的关系备受关注。
Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secre- tagogue receptor in 1999. Ghrelin exerts wide physiological actions throughout the body, including growth hormone se- cretion, appetite and food intake, gastric secretion and gastrointestinal motility, glucose homeostasis and liver protec- tion. Increasing studies indicate the changes of Ghrelin in liver diseases, revealing an liver protection function by anti- inflammatory functions, reducing oxidative stress and apoptosis, anti-fibrosis. This review summarized the role of Ghrelin in liver diseases.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第5期615-618,共4页
Chinese Journal of Gastroenterology and Hepatology
