摘要
目的 ：Meta分析保乳术后全乳放疗联合瘤床补量放疗对乳腺导管原位癌（ductal carcinoma in situ,DCIS）患者局部复发的短期和长期控制效果,以及对同侧浸润性乳腺癌局部复发的控制效果。方法 ：计算机检索Pubmed、中国期刊全文数据库（China Journal Full-text Database,CJFD）、中国生物医学文献数据库（China Biology Medicine disc,CBMdisc）、Embase数据库和Cochrane Library数据库,筛选符合文献纳入标准的研究。采用纽卡斯尔-渥太华质量评价量表（Newcastle-Ottawa Quality Assessment Scale）对文献进行质量评估。应用Rev Man 5.3软件进行Meta分析。结果 ：共纳入14项非随机对照研究（13项为队列研究,1项为非同期对照试验）,包括8 679例研究对象。Meta分析结果显示,保乳术后全乳放疗与保乳术后全乳放疗联合瘤床补量放疗的5年局部复发率（比值比为0.92,95%可信区间为0.46~1.82,P=0.81）、7年局部复发率（比值比为0.70,95%可信区间为0.45~1.09,P=0.11）、≥10年局部复发率（比值比为0.95,95%可信区间为0.79~1.15,P=0.62）和同侧浸润性乳腺癌局部复发率（比值比为0.89,95%可信区间为0.62~1.29,P=0.55）差异均无统计学意义。结论 ：与全乳放疗相比,全乳放疗联合瘤床补量放疗不能降低乳腺DCIS患者保乳术后的5年、7年及≥10年的局部复发率,也不能降低同侧浸润性乳腺癌的局部复发率。
Objective：To conduct a Meta-analysis to analyze the short-term and long-term preventive effects of whole breast irradiation combined with tumor bed boost on short- and long-term local recurrence rates and local recurrence rate of ipsilateral invasive breast cancer in patients with breast ductal carcinoma in situ（DCIS）after breast conserving-surgery（BCS）.Methods：A computer-based online search of PubMed,China Journal Full-text Database（CJFD）,China Biology Medicine disc（CBMdisc）,Embase and Cochrane Library was performed to include eligible studies in accordance with the inclusion and exclusion criteria.NewcastleOttawa Quality Assessment Scale was used for quality assessment of included articles.RevMan 5.3 software was used for Meta-analysis.Results：A total of 14 non-randomized controlled trials（13 were cohort study,and 1 was nonsimultaneous controlled trial） involving 8 679 patients with breast DCIS were included.The results of this Meta-analysis showed that no statistically significant differences between whole breast irradiation and whole breast irradiation combined with tumor bed boost in terms of5-year local recurrence rate[odds ratio（OR） = 0.92,95%confidence interval（CI）：0.46-1.82;P = 0.81],7-year local recurrence rate（OR = 0.70,95%CI：0.45-1.09;P = 0.11）, 10-year local recurrence rate（OR = 0.95,95%CI：0.79-1.1 5;P = 0.62） and the local recurrence rate of ipsilateral invasive breast cancer（OR = 0.89,95%Cl：0.62-1.29;P = 0.55）.Conclusion：As compared with whole breast irradiation,the whole breast irradiation combined with tumor bed boost in patients with DCIS after BCS can not obviously decrease the 5-year,7-year and 1 0-year local recurrence rates,as well as the local recurrence rate of ipsilateral invasive breast cancer.
出处
《肿瘤》
CAS
CSCD
北大核心
2015年第5期556-564,共9页
Tumor
关键词
乳腺肿瘤
乳腺导管原位癌
放射治疗
全乳放疗
瘤床补量
META分析
Breast neoplasms Breast ductal carcinoma in situ Radiation therapy Whole breast irradiation Tumor bed boost Meta-analysis
