摘要
Background： Statins have proven efficacy in inhibiting the onset and progress of atherosclerosis. The effectiveness of pitavastatin in reversing carotid atherosclerosis associated with hypercholesterolemia （HC） is un-known. Objectives： To explore the simultaneous effects of pitavastatin calcium on brachial arterial flow-mediated vasodilatation （FMD）, carotid intima-media thickness （IMT）, and arterial stiffness （β）, three surrogate markers of ath-erosclerosis were studied in HC patients. Methods：A randomized, double-blind trial was performed with 40 HC sub-jects who fulfil ed the inclusion/exclusion criteria. Patients were given pitavastatin calcium 1 mg/d （Group 1） or 2 mg/d （Group 2） for 8 weeks. There were 20 patients in each group, and 30 gender-and age-matched healthy subjects as controls were recruited. FMD of the brachial artery, carotid IMT, and arterial stiffness indicated byβwere measured at baseline and at 8 weeks after starting pitavastatin calcium therapy using ultrasound techniques. Biochemical tests were also made on al subjects. Results： At baseline, higher total cholesterol （TC） and low-density lipoprotein cho-lesterol （LDL-C）, reduced FMD, and increasedβand IMT were observed in HC patients （P0.05）. Significant negative interactions between TC/LDL and FMD （P〈0.05–0.001）, positive interactions between TC and IMT （P=0.003） and between TC/LDL and β （P〈0.001–0.000） were found. Conclusions： Treatment with pitavastatin calcium exerted fa-vorable effects on endothelial function and arterial stiffness. It also improved carotid atherosclerosis in patients with HC.
目的：观察匹伐他汀钙对高胆固醇血症患者外周血管的影响。创新点：首次在国内发现匹伐他汀钙能够改善高胆固醇血症患者肱动脉和颈动脉血管内皮功能而且延缓其动脉粥样硬化发展，并首次证实改善内皮功能是匹伐他汀钙延缓其动脉粥样硬化发展的重要原因。方法：按照入选排除标准，选取本院高胆固醇血症患者（HC），完成超声心动图检查的40例。根据剂量不同，分为两个剂量组：1 mg剂量组20例（男性5例，女性15例，平均年龄（55.20±8.35）岁），2 mg剂量组20例（男性9例，女性11例，平均年龄（57.56±6.09）岁）。访视结束后完成超声心动图检查的HC组36例，两个剂量组分别有2人失访。治疗后1 mg剂量组18例（男性3例，女性15例，平均年龄（56.00±7.85）岁），2 mg剂量组18例（男性7例，女性11例，平均年龄（57.79±6.46）岁）。选择本院同期体检中心30例正常人作为对照（年龄和性别均与病例组匹配，男性14例，女性16例，平均年龄（54.94±6.90）岁）。所有研究对象，均经隔夜禁食12～14小时，次日清晨抽取空腹肘静脉血，测定临床生化指标。采用Sequia 512彩色多普勒超声诊断仪，应用高分辩率外周血管超声技术，检测HC治疗前后肱动脉血流介导性舒张功能（FMD）、颈动脉结构和功能。 结论：经匹伐他汀钙治疗8周后，高胆固醇血症患者血管功能明显改善，表现为 FMD升高，僵硬度减小；颈动脉僵硬度和内中膜厚度（IMT）延缓进展与其内皮功能改善密切相关。
基金
Project supported by the National Science and Technology Major Project(No.2012ZX09303-016-003)
the National Natural Science Foundation of China(Nos.81270352,81270287,81300168,81471036,and 81470560)
