摘要
目的探讨丹参注射液联合布地奈德/福莫特罗对急性加重期老年COPD患者血气指标、血液流变学、内皮细胞功能的影响。方法将216例急性加重期老年COPD患者随机分成2组,各108例。对照组给予布地奈德/福莫特罗,观察组在对照组基础上加用丹参注射液。对2组患者血气指标(Pa O2、Pa CO2、p H)、血液流变学指标(HBV、LBV、PV、TK、PF)、内皮细胞功能(ET-1、NO)进行检测。结果治疗后,2组Pa O2水平明显增大(P<0.05),且观察组Pa O2水平明显大于对照组(P<0.05);治疗后,2组Pa CO2水平明显减小(P<0.05),且观察组Pa CO2水平明显小于对照组(P<0.05)。治疗后,2组HBV、LBV、PV、TK、PF水平明显减小(P<0.05),且观察组HBV、LBV、PV、TK、PF水平明显小于对照组(P<0.05)。治疗后,2组ET-1水平明显减小(P<0.05),且观察组ET-1水平明显小于对照组(P<0.05);治疗后,2组NO水平明显增大(P<0.05),且观察组NO水平明显大于对照组(P<0.05)。结论丹参注射液联合布地奈德/福莫特罗可有效改善急性加重期老年COPD患者血气指标、血液流变学、内皮细胞功能。
Objective To investigate the influence of salvia mihiorrhiza injection combined with budesonide and salmet- erol inhalation on blood gas index, hemorheology and endothelial cell function of elder patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods 216 cases of elder patients with acute exacerbation of COPD were randomly divided into two groups with 108 cases in each group. The patients in the control group were given budes- onide and salmeterol inhalation, and the patients in the observation group were given salvia mihiorrhiza injection based on the treatment in the control group. The blood gas index （ PaO2, PaCO2, pH）, hemorheology （ HBV, LBV, PV, TK, PF） and endothelial cell function（ET-1, NO） of both groups were detected. Results After the treatment, PaO2 levels of both groups were significantly increased（ P 〈 0.05 ）, and PaO2 level of the observation group was significantly higher thanthat in the control group （ P 〈 0.05 ） ; After the treatment, PaCO2 levels of both groups were significantly reduced （ P 〈 0. 05 ）, and PaCO2 level of the observation group was significantly low than that in the control group（P 〈 0.05 ）. After the treat- ment, HBV, LBV, PV, TK and PF levels of both groups were significantly reduced （ P 〈 0.05 ）, and HBV, LBV, PV, TK and PF levels of the observation group were significantly low than those in the control group （P 〈 0.05 ）. After the treat- ment, ET-1 levels of both groups were significantly reduced（P 〈 0.05 ）, and ET-1 level of the observation group was sig- nificantly low than that int the control group（ P 〈 0.05 ） ;After the treatment, NO levels of both groups were significantly increased（P 〈 0.05）, and NO level of the observation group was significantly higher than that in th econtrol group（P 〈 0. 05 ）. Conclusion Salvia miltiorrhiza injection combined with budesonide and salmeterol inhalation can effectively im- prove blood gas index, hemorheology and endothelial ce
出处
《中华全科医学》
2015年第7期1057-1059,共3页
Chinese Journal of General Practice
基金
广东省自然科学基金项目(S2011010002100)
关键词
慢性阻塞性肺疾病
丹参注射液
布地奈德/福莫特罗
血气指标
血液流变学
内皮细胞功能
Chronic obstructive pulmonary disease
Salvia mihiorrhiza injection
Budesonide and salmeterol inhalation
Blood gas parameters
Hemorheology
Endothelial cell function
