摘要
目的探究乳腺癌术后服用中药对其复发转移的影响。方法采集符合纳入标准的乳腺癌女性病例共120例,详细记录影响复发转移的因素以及术后服用中药情况;同时记录复发转移等预后相关的资料,并计算出患者的无病生存时间(DFS)。最后采用回顾性分析的研究方法,观察中医治疗对复发转移时间的影响。结果 120例女性患者中,持续服用中药的患者总复发转移率为81.6%,中位无病生存时间为60月,5年无病生存时间率为45%;未持续服用的患者总复发转移率为96%,中位无病生存时间为33月,5年无病生存时间率为20%;未服用者全部发生了复发转移,中位无病生存时间为16月,5年无病生存时间率为0%。经统计,是否服用中药和是否持续服用中药分别与无病生存时间的相关性具有统计学意义(P<0.05)。对于不同分期的患者,Ⅱ期和ⅢA期患者是否服用中药和其无病生存时间之间有显著相关性(P<0.05),ⅢC期患者则无统计学意义(P>0.05)。结论初步判断,长期服用中药可能有益于延长无病生存时间。
ABSTRACT：OBJECTIVE To explore the influence of Chinese medicine intervention on recurrence and metastasis in postoper-ative patients with breast cancer.METHODS Totally 120 cases of female breast cancer meeting the requirement of the inclu-sive criteria were collected,the influencing factors of recurrence and metastasis,Chinese drug-taking situations and the related prognostic dates were recorded in detail and the disease free survival time was calculated.Subsequently,the influence of Chi-nese medicine on relapse and transfer time was observed by applying the method of retrospective analysis.RESULTS Among the 120 female cases,compared with the total recurrence and metastasis rate of the patients who persisted in taking Chinese medicine being 81.6%,with a 60-month median disease free survival and 45% five-year disease free survival rate,the total rate of those who did not continuously take Chinese drugs was 96%,with a 33-month median disease free survival and 20% five-year disease free survival rate,and the total rate of those who took no Chinese medicine was 100%,with a 16-month median disease free survival and 0% （none） five-year disease free survival rate.According to statistics,there were significant differ-ences between whether taking Chinese medicine or not and the disease free survival time,as well as between the duration of drug-taking and the disease free survival time （P 〈 0.05）;In terms of patients in different stages,whether taking Chinese medicine or not of patients in both theⅡand ⅢA stage are correlated significantly with their disease free survival time（P 〈0.05）,while no statistical significances were found in the ⅢC stage（P 〉0.05）.CONCLUSION We can make a pre-judge-ment that the long-term use of Chinese medicine may be beneficial to prolong the disease free survival time.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2015年第3期295-297,共3页
Journal of Nanjing University of Traditional Chinese Medicine
关键词
中医药治疗
乳腺癌术后
复发转移
Chinese medicine treatment
postoperative breast cancer
recurrence and metastasis
