摘要
目的:观察活血益肾中药联合西药治疗糖尿病肾病的临床疗效,为临床治疗提供参考。方法:选取95例糖尿病肾病患者作为研究对象,随机分为两组,对照组47例进行常规西医治疗,治疗组48例在对照组基础上加用活血益肾中药治疗。观察两组患者治疗前后临床疗效、24 h尿蛋白排出量、空腹血糖等指标变化。结果:治疗组临床总有效率为91.67%,对照组为78.72%,经卡方检验,差异有统计学意义,P<0.05;2个疗程后,治疗组尿白蛋白排泄率(UAER)、尿素氮(BUN)和血肌酐(Scr)水平分别为(56.20±19.45)μg/min、(4.68±1.00)mmol/L和(75.70±19.55)μmol/L,对照组分别为(74.35±21.50)μg/min、(6.35±1.12)mmol/L和(96.76±26.50)μmol/L,经t检验,差异有统计学意义,P<0.05;治疗组总不良反应发生率为10.42%,对照组为8.51%,经卡方检验,差异无统计学意义,P>0.05。结论:活血益肾中药联合西药治疗糖尿病肾病具有较好的临床疗效,值得推广应用。
Objective: To observe the clinical curative effect of Huoxue Yishen Decoction combined with western medicine in treatment of early diabetic nephropathy,and provide reference for clinical treatment. Methods: 95 cases of diabetic nephropathy patients diagnosed and treated in our hospital were selected as the research object. They were randomly divided into 2 groups. 47 patients treated with western medicine were as control group and 48 patients treated with western and Chinese medicine were as treatment group. The clinical curative effect before and after treatment,24 h urinary protein excretion,fasting blood sugar and other index changes were observed in two groups. Results: The total effective rate in treatment group and control group were 91. 67% and 78. 72%,respectively. The difference was statistically significant by the chi- square test,P〈0. 05. After 2 courses,urinary albumin excretion rate( UAER),urea nitrogen( BUN) and serum creatinine( Scr) in treatment group were( 56. 20 ± 19. 45) μg / min,( 4. 68 ± 1. 00) mmol / L and( 75. 70 ± 19. 55) mol /L,respectively. These indexes in the control group were( 74. 35 ± 21. 50) μg / min,( 6. 35 ± 1. 12) mmol / L and( 96. 76± 26. 50) μmol / L,respectively. The difference was statistically significant by t test,P〈0. 05. The total incidence of adverse reactions in treatment group and control group was 10. 42% and 8. 51%,respectively. There was no statistically significant difference by the chi- square test,P〉0. 05. Conclusion: Huoxue Yishen Decoction combined with western medicine in treatment of diabetic nephropathy has good curative effect. It is worth popularization and application.
出处
《中华中医药学刊》
CAS
北大核心
2015年第6期1396-1398,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省科技厅项目[zj(z)2011-2-4-3A-5]
关键词
糖尿病肾病
活血益肾中药
疗效
diabetic nephropathy
invigorating the kidney medicine
curative effect