摘要
目的:比较经尿道2微米激光切除术与电切术治疗浅表性膀胱癌的临床疗效。方法:按照随机数字表法将2014年1月-2015年1月我院收治的浅表性膀胱癌患者分为两组,观察组(61例)行经尿道2微米激光切除手术,对照组(46例)行电切术,比较两组的手术效果、治疗前后的炎症因子水平及并发症。结果:观察组手术时间、导尿管留置时间、住院时间及术中出血量少于对照组,差异有统计学意义(P<0.05)。治疗后两组患者IL-6、IL-10以及TNF-α水平均较治疗前升高,但是观察组治疗后的IL-6及TNF-α水平低于对照组,IL-10水平高于对照组,差异有统计学意义(P<0.05)。两组患者术后均发生不同程度的并发症,其中观察组膀胱穿孔、闭孔神经反射的发生率为3.28%、1.64%,分别低于对照组的17.39%、13.04%,差异有统计学意义(P<0.05)。结论:浅表性膀胱癌采用经尿道2微米激光切除术治疗具有明显的临床手术效果,减少术后并发症,同时对患者炎症因子的影响较小,临床有重要的参考价值。
Objective： To compare the clinical effect of transurethral 2 micron laser resection and electrocision for superficial bladder cancer. Methods： A total of 107 patients with superficial bladder cancer, who were admitted to First Affiliated Hospital of Chongqing Third Military Medical University from January 2014 to January 2015, were randomly divided into observation group（n=61）and control group（n=46）. The observation group underwent transurethral 2 micron laser resection, while the control group underwent electrocision. The operation effect, inflammation factors levels before and after operation, and the complications were compared. Results：Operation time, indwelling catheter time, hospitalization time and intraoperative amount of bleeding in the observation group were less than those in the control group, the differences were statistically significant（P〈0.05）. The levels of IL-6, IL-10 and TNF-α in the two groups after treatment were higher than those before treatment, but the levels of IL-6 and TNF-α in the observation group after treatment were lower than those in the control group, while IL-10 level was higher than that in the control group, the differences were statistically significant（P〈0.05）. There were complications in the two groups after treatment, the incidence of bladder perforation（3.28%） and obturator nerve reflex（1.64%） in the observation group were lower than those（17.39% and 13.04%） in the control group, the differences were statistically significant（P〈0.05）. Conclusion： Transurethral 2 micron laser resection has remarkable operation effect in the treatment of patients with superficial bladder cancer, with reducing the postoperative complication and slightly influencing the inflammatory factors level, which has an important reference value in the clinical field.
出处
《现代生物医学进展》
CAS
2015年第18期3513-3516,共4页
Progress in Modern Biomedicine
关键词
经尿道2微米激光切除术
电切术
浅表性膀胱癌
临床疗效
Transurethral 2 micron laser resection
Electrocision
Superficial bladder cancer
Clinical effect
