摘要
目的:观察丹参川芎嗪用于慢性阻塞性肺疾病(chronic obstr-uctive pulmonary disease,COPD)急性加重期并肺源性心脏病患者的疗效及机制。方法:选择COPD急性加重期并慢性肺源性心脏病期患者90例,随机分为丹参川芎嗪组和对照组,每组45例。两组均给予对症治疗,丹参川芎嗪组在对症治疗基础上加用丹参川芎嗪注射液5 mL(溶解于250 mL5%葡萄糖液),静脉滴注,1次/d。两组均治疗15 d。检测两组患者治疗前后的血气分析指标[动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)]、血流动力学指标[肺动脉收缩压(PASP)、舒张压(PADP)、平均肺动脉压(MPAP)]、血管活性因子指标[内皮素-1(ET-1)、一氧化氮(NO)]。结果:两组患者治疗前各项指标差异无统计学意义。治疗后两组患者的各项指标均较治疗前改善(P<0.05、0.01),其中丹参川芎嗪组患者改善更显著。结论:丹参川芎嗪治疗COPD急性加重期并肺源性心脏病的疗效较好,能够改善肺组织氧供,减少ET-1生成,增加NO的释放,降低肺动脉高压,改善心肺功能。
Objective：To observe efficacy and mechanism of salvia miltiorrhiza and tetramethylpyrazine in the treatment of acute exacerbation of chronic obstructive pulmonary disease（COPD） accompanied by pulmonary heart disease .Methods：A total of 90 patients with acute exacerbation of COPD accompanied by pulmonary heart disease were randomly selected and divided into two groups ,the salvia miltiorrhiza and tetramethylpyrazine group and the control group ,with 45 cases in each .Both groups were given symptomatic treatment ,and the salvia miltiorrhiza and tetramethylpyrazine group received 5 mL salvia miltiorrhiza and tetramethylpyrazine injection（dissolved in 250 mL 5% glucose solution） by intravenous infusion once a day in addition .Both the two groups have been treated for 15 days .The blood gas analysis indexes（PaO2 ,SaO2 ） ,the hemodynamic indexes（PASP ,PADP ,MPAP） ,and the vasoactive factor indexes（ET‐1 ,NO） of the patents in two groups were detected before and after the treatment .Results：There was no statistically significant difference between the two groups in each index before the treatment .Each index of patients in both two groups improved after the treatment ,compared with that before the treatment（P〈 0 .05、0 .01） , of which the patients in salvia miltiorrhiza and tetramethylpyrazine group improved more significantly .Conclusions：Salvia miltiorrhiza and tetramethylpyrazine showed good efficacy on acute exacerbation of COPD accompanied by pulmonary heart disease .It could improve the oxygen supply for lung tissue ,reduce the generation of ET‐1 , increase the release of NO ,reduce the PASP and improve the cardiopulmonary function .
出处
《中国临床医学》
2015年第2期189-191,共3页
Chinese Journal of Clinical Medicine
关键词
慢性阻塞性肺疾病
慢性肺源性心脏病
丹参川芎嗪
Chronic obstructive pulmonary disease
Chronic pulmonary heart disease
Salvia miltiorrhiza and tetramethylpyrazine
