摘要
目的:探讨晚期糖基化终末产物受体(RAGE)及基质金属蛋白酶-9(MMP-9)在乳腺癌组织中的表达并分析其与临床相关病理因素的关系。方法:采用免疫组化法检测RAGE和MMP-9在60例乳腺癌组织及37例正常乳腺组织中的表达,并分析其与乳腺癌分化程度、浸润深度、淋巴结转移及TNM分期之间的关系。结果:RAGE及MMP-9在乳腺癌中的阳性表达率分别为70.00%和61.67%。乳腺癌病理分级、淋巴结转移与RAGE及MMP-9高表达密切相关(P<0.05),RAGE表达水平与MMP-9表达水平呈正相关(P<0.05)。结论:RAGE和MMP-9的表达水平可能与乳腺癌发生及转移密切相关,可作为乳腺癌药物治疗的重要靶点。
Objective： To explore the expressions of RAGE and MMP- 9 in breast cancer and the relationship with related clinicopathological factors. Methods： Immunohistochemical method was used to detect the expressions of RAGE and MMP- 9 in 60 cases with breast cancer and 37 cases with normal breast tissue. The relationship between RAGE and MMP- 9 expressions and differentiation degree,depth of invasion,lymph node metastasis,and TNM stage was analyzed. Results： The positive expression rates of RAGE and MMP- 9 in breast cancer were 70. 00% and 61. 67%,respectively; pathological grade and lymph node metastasis were closely correlated with high expressions of RAGE and MMP- 9（ P 〈0. 05）,RAGE expression level was positively correlated with MMP- 9 expression level（ P〈 0. 05）.Conclusion： The expression levels of RAGE and MMP- 9 may be closely correlated with occurrence and metastasis of breast cancer,which can be used as important targets for drug therapy of breast cancer.
出处
《中国妇幼保健》
CAS
2015年第16期2645-2648,共4页
Maternal and Child Health Care of China
基金
黑龙江省教育厅项目〔12541903〕
