摘要
目的观察肝豆状核变性(HLD)及不同临床分型患者血常规各项指标水平,探讨其相关病理机制。方法对493例HLD患者和153例正常对照组用sysmex XT-2000五分类血细胞计数仪检测19项血常规项目。结果 HLD组WBC、NEUT%、RBC、HGB、HCT、MCV、MCH、MCHC、PLT、PCT与正常对照组比较均显著降低,而LYMPH%、MONO%、EO%、RDW-CV%与正常组相比均升高,且差异均有统计学意义(P<0.01)。MPV、PDW、PLCR与正常组比较差异无统计学(P>0.05);HLD患者肝型、脑型、脑内脏型3种临床分型血常规分析:3种临床分型以WBC、RBC、HGB、PLT水平降低比较明显,其中脑内脏型患者WBC、PLT低于标准的异常率明显高于其他两组。结论 HLD患者血细胞各项指标均有异常,对临床的诊断、治疗有指导价值。
Objective To observe the change of routine blood test indicators' levels in patients with hepato-lenticular degeneration and to discuss the underlying pathomechanism. Methods Nineteen items of routine blood were tested with sysmex XT-2000 blood analyzer in the experimental group of patients with HLD(n=493) and the control group of healthy people(n=153). Results The levels of WBC, NEUT％, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, PCT of HLD patients were significantly below the normal range. The levels of LYMPH％, MONO％, EO％, RDW-CV were significantly higher than the normal range, they showed the difference compared with normal control (P＜0.01), while no difference in MPV, PDW, PLCR(P＜0. 05). Routine blood test analysis of three clinical types of HLD:WBC, RBC, HGB, PLT levels of three clinical types were decreased obviously;the abnormal rate of brain-viscus type's WBC and PLT levels lower than the standard was higher than that in the other two groups;it was related with the nervous system and the liver, kidney, spleen and other multiple organ damage. Conclusion Indicators of HLD's routine blood are abnormal, which may guide the clinical diagnosis and treat-ment.
出处
《安徽医学》
2015年第5期516-518,共3页
Anhui Medical Journal
基金
国家自然科学基金资助面上项目(编号:81473535)
关键词
肝豆状核变性
静脉血细胞
白细胞
血小板
Hepato-lenticular degeneration
Venous blood cell
White blood cell
Platelet
