摘要
目的:考察注射用喷昔洛韦、注射用促肝细胞生长素、单硝酸异山梨酯注射液、细辛脑注射液与临床常用输液的配伍稳定性,为临床用药提供参考。方法:采用紫外分光光度法测定6h内混合液中药物的含量及紫外图谱变化,并观察不同时间点液体的外观和pH值变化。结果:以上4种药物与输液溶媒配伍后6h内外观、pH值均无明显变化。注射用喷昔洛韦与0.9%氯化钠注射液(NS)、5%葡萄糖注射液(GS)、10%GS、5%葡萄糖氯化钠注射液(GNS),注射用促肝细胞生长素与10%GS,单硝酸异山梨酯注射液与5%GS和果糖注射液,细辛脑注射液与10%GS、5%GNS配伍后6h药物含量与图谱无明显变化。单硝酸异山梨酯注射液与NS和转化糖注射液配伍,4h时药物含量分别降至95.07%和93.98%。注射用促肝细胞生长素与NS配伍后6h时含量降至75.92%。细辛脑注射液与NS、5%GS配伍后6h含量分别降至94.72%和95.72%。结论:以上4种药物与不同的输液溶媒配伍后,药品的含量随着放置时间的延长会发生变化,其中注射用促肝细胞生长素含量变化尤其明显,提示在临床应用过程中,药品配制完毕后需减少放置时间,以保证药品质量,确保病人的用药安全。
Objective：To study the stability of penciclovir,hepatocyte growth-promoting factor（HGPF）,isosorbide mononitrate and asarone for injections mixed with the commonly used solvents,so as to provide evidence for clinical medication.Methods：Ultraviolet（UV）spectrophotometry was used to monitor changes in the contents of the drugs in the mixed solutions within 6hours and UV spectra as well,and also to observe changes in the outward appearance and pH values of the solutions at different time points.Results：No significant changes could be noted in the outward appearance and pH values of the mixed solutions of the 4drugs within 6hours.Significant changes could neither be noted in the contents of the drugs and UV spectra within 6hours,when（1）penciclovir was mixed with normal saline（NS）,5% glucose injection（GS）,10%GS,5% glucose in normal saline（GNS）;（2）HGPF was mixed with 10%GS;（3）isosorbide mononitrate was mixed with 5%GS and fructose injection;（4）asarone was mixed with 10%GS and 5%GNS.When isosorbide mononitrate injection was mixed with NS and invert sugar injection,drug levels at hour 4were decreased to 95.07% and 93.98%.The level of HGPF was decreased to 75.92% at hour 6,when it was mixed with NS.The levels of asarone were respectively decreased to 94.72% and 95.72% at hour 6,when it was mixed with NS and 5%GS.Conclusion：When the above 4drugs were mixed with different solvents,changes would occur in drug levels with the extension of time,with the changes in HGPF being most prominent.It was indicated that drug preparations should not be left there too long,once they were mixed with solvents,so as to ensure drug quality and safety in clinical medication.
出处
《药学服务与研究》
CAS
2015年第2期138-140,共3页
Pharmaceutical Care and Research
基金
山东省药学会临床药学奥赛康中青年科研资助项目(Sdpa-ask-2012-06)
