摘要
目的对垂体腺瘤患者术后脑脊液漏继发颅内感染进行临床分析及防治措施研究,为减少垂体腺瘤患者医院感染提供临床参考依据。方法选取医院2010年6月-2014年6月收治的1 023例垂体腺瘤患者,对垂体腺瘤术后脑脊液漏继发颅内感染患者进行临床分析,并制定相应预防措施;采用SPSS17.0软件进行统计分析。结果 1 023例垂体腺瘤患者,53例患者发生感染,感染率为5.18%;多因素logistic回归分析显示,术后脑脊液漏、侵入性操作、激素治疗是垂体腺瘤术后脑脊液漏继发颅内感染的危险因素,使用抗菌药物是垂体腺瘤术后脑脊液漏继发颅内感染的保护因素;感染患者进行防治干预后,感染率下降为2.74%,生活质量升高。结论术后脑脊液漏、侵入性操作、激素治疗是垂体腺瘤术后脑脊液漏继发颅内感染的危险因素,对感染患者进行针对性的防治干预,可降低患者的感染率,提高生活质量。
OBJECTIVE To conduct clinical analysis of postoperative cerebrospinal fluid leakage with secondary in‐tracranial infections in the pituitary adenoma patients and put forward prevention measures so as to provide guid‐ance for reduction of incidence of nosocomial infections in the pituitary adenoma patients .METHODS A total of 1 023 pituitary adenoma patients who were treated from Jun 2010 to Jun 2014 were enrolled in the study ,then the clinical analysis was conducted to observe the risk factors for the postoperative cerebrospinal fluid leakage with secondary intracranial infections ,the corresponding prevention measures were put forward ,and the statistical analysis was performed with the use of SPSS17 .0 software .RESULTS The infections occurred in 53 of 1 023 pitui‐tary adenoma patients ,with the infection rate of 5 .18% .The multivariate logistic regression analysis indicated that the postoperative cerebrospinal fluid leakage ,invasive operation ,and hormone therapy were the risk factors for the postoperative cerebrospinal fluid leakage with secondary intracranial infections in the pituitary adenoma pa‐tients ,and the use of antibiotics was the protective factor .The infection rate was decreased to 2 .74% and the qual‐ity of life was improved after the prevention interventions were taken .CONCLUSION The postoperative cerebrospi‐nal fluid leakage ,invasive operation ,and hormone therapy are the risk factors for the postoperative cerebrospinal fluid leakage with secondary intracranial infections in the pituitary adenoma patients ,and it is an effective way to take targeted interventions so as to reduce the infection rate and improve the quality of life .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第10期2306-2308,共3页
Chinese Journal of Nosocomiology
基金
山东省自然科学基金资助项目(Y2006C02)
关键词
垂体腺瘤
手术脑脊液漏
颅内感染
防治措施
Pituitary adenoma
Surgery cerebrospinal fluid leakage
Intracranial infection
Prevention measure
