摘要
目的 :探讨乳腺癌组织中Ki67、p53的表达与彩色多普勒超声征象的相关性及意义。方法 :回顾性描述经手术病理证实为乳腺癌的135例患者彩色多普勒超声征象,包括肿块大小、边缘、形态,钙化分布和形态,血流显像分级,淋巴结转移及侵犯周围组织,并采用免疫组化方法检测Ki67、p53的表达情况,分析其与超声表现的相关性。结果:Ki67、p53在乳腺癌组织的阳性率分别为64.4%(87/135),51.1%(69/135)。Ki67、p53表达与肿块大小、肿块边缘无相关性(P>0.05),与血流显像分级、淋巴结转移及侵犯周围组织有显著性相关(P<0.05)。Ki67与肿块形态、钙化形态有显著相关性(P<0.05),与钙化分布无相关性(P>0.05),而p53与肿块形态、钙化形态无相关性(P>0.05),与钙化分布有显著性相关(P<0.05)。Ki67与p53表达程度呈正相关(r=0.617,P<0.05)。结论 :乳腺癌超声征象与Ki67、p53表达存在相关性,在乳腺癌非手术治疗、术前及术后风险评估中具有潜在的临床应用价值。
Objective： To investigate the expression of Ki67 and p53 in breast cancer, and their correlation with color Doppler ultrasound features. Methods： 135 cases of breast cancer confirmed by pathology were retrospectively enrolled for the color Doppler ultrasound features, including tumor size, edge, shape, distribution and morphology of calcification, flowing image grading, lymph node metastasis and surrounding tissues invasion. The expression of Ki67 and p53 was detected with immuno- histochemical methods and their correlations with color Doppler ultrasound features were analyzed. Results： The positive rate of Ki67 and p53 in breast cancer tissue were 64.4%（87/135） and 51.1%（69/135） respectively. The expression of Ki67 and p53 showed no correlation with tumor size and tumor edge （P〉0.05）, but correlated significantly with flowing image grading, lymph node metastasis and surrounding tissues invasion （P〈0.05）. The expression of Ki67 had significant correlations with tumor mor- phology and calcification （P〈0.05）, but no correlation with the distribution of calcification （P〉0.05）. The expression of p53 had no correlation with tumor morphology and shape of calcification（P〉0.05）, but significant correlation with the distribution of cal- cification（P〈0.05）. The expressions of Ki67 and p53 were positively correlated（r=0.617, P〈0.05）. Conclusion： There were corre- lations between ultrasound features and expression of Ki67 and p53 in breast cancer. Color Doppler ultrasound features may play a potential role in clinical application of non-surgical treatment and presurgical assessment of breast cancer.
出处
《中国临床医学影像杂志》
CAS
北大核心
2015年第5期321-324,共4页
Journal of China Clinic Medical Imaging
基金
辽宁省自然科学基金(2010010286-401)
