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丙型肝炎肝硬化患者预后相关危险因素分析 被引量:7

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摘要 目的:评价影响丙型肝炎肝硬化患者预后的相关危险因素。方法:对我院2002-2011年期间收治的丙肝肝硬化患者资料进行研究,并对其进行规律随访。首先对各潜在预后相关危险因素与生存情况或肝移植情况的关系分别进行单因素分析,再将其有统计学意义的指标分别纳入 Logistic 回归及 COX 回归模型。结果:共纳入572例丙肝患者,其中143例合并肝硬化,男103例(72.03%),平均年龄59(51~71)岁。在143例肝硬化患者中,57例(39.86%)患有糖尿病,41例(28.67%)有大量饮酒史,3例(2.10%)存在 HBV感染。经统计分析发现,终末期肝病评分≥10分、糖尿病及合并HBV感染与无肝移植生存期有明显相关性(P <0.05),糖尿病与腹水、细菌感染及肝性脑病明显相关(P <0.05)。随访分析发现糖尿病与肝病腹水进展、细菌感染、肾功能紊乱及肝癌有明显相关性(P <0.05)。结论:糖尿病是丙肝肝硬化患者预后的独立危险因素,控制糖尿病有可能提高该类患者的生存质量。
出处 《实用医学杂志》 CAS 北大核心 2015年第9期1443-1445,共3页 The Journal of Practical Medicine
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