摘要
目的探讨原发性中枢神经系统淋巴瘤(PCNSL)患者DWI的ADC值与无进展生存期(PFS)、Ki-67标记指数之间相关性。方法分析经临床和病理证实的28例PCNSL的MRI和免疫组化结果。分别测量肿瘤的ADC值并记录最小ADC值(ADCmin)、平均ADC值(ADCmean)及最大ADC值(ADCmax),并进行统计学分析。结果 28例中15例单发,13例多发。PFS与ADCmin呈正相关(r=0.565,P=0.002),PFS与Ki-67呈负相关(r=-0.627,P<0.001)。PFS与ADCmean、ADCmax均无相关性(r=0.324、-0.056,P=0.093、0.776)。Ki-67与ADCmin呈负相关(r=-0.575,P=0.001),Ki-67与ADCmean和ADCmax间均无相关性(r=-0.273、-0.094,P=0.159、0.636)。强化灶单发与多发患者间Ki-67和PFS以及≥60岁和<60岁间PFS差异均无统计学意义(P均>0.05)。结论 DWI可在治疗前初步判断PCNSL的PFS。
Objective To investigate the correlation between progression-free survival （PFS）, labeling index of Ki-67 and ADC values in the primary central cerebral system lymphoma （PCNSL）. Methods MRI features and the Ki-67 expression level of 28 PCNSL patients confirmed by clinics and pathology were analyzed retrospectively. Minimum ADC value （ADCmln）, mean ADC value （ADC ） and the maximum ADC value （ADCmax） were measured and statistically analyzed. Results Twenty-eight cases included 15 cases of single and 13 cases of multiple. There was positive correlation between PFS and ADCman （r=0. 565, P=0. 002）, negative correlation between PFS and Ki-67 （r=--0. 627, P〈0. 001）. And there was no correlation between the PFS and ADC ADC （r= 0. 324, =0. 056, P =0. 093, 0. 776）. There was negative correlation between Ki-67 and ADCmln （r=-0. 575, P=0. 001）, and there was no correlation between Ki-67 and ADC ADCmax（r=-0. 273,-0. 094, P=0. 159, 0. 636）. The level of Ki-67 and PFS showed no significant difference between the patients of single lesions and multiple lesions （P〈0.05）. PFS showed no significant difference between patients ≥60 years and 〈60 years old （all P〈0.05）. Conclusion ADC value may be a predictable factor on PFS of PCNSL patients.
出处
《中国医学影像技术》
CSCD
北大核心
2015年第5期711-715,共5页
Chinese Journal of Medical Imaging Technology
关键词
中枢神经系统
淋巴瘤
磁共振成像
无进展生存期
Central nervous system
Lymphoma
Magnetic resonance imaging
Progression-free survival
