摘要
邻苯二甲酸二(2-乙基己)酯是使用十分广泛的塑化剂,为人类内分泌干扰物。目前对其致病机制尚不清楚。现有研究认为,其可能具有内分泌干扰、氧化损伤、免疫紊乱和遗传物质改变等多系统、多途径的毒性。其内分泌干扰主要表现为可能通过多途径干扰雄性生殖系统发育及功能,对雌性生殖系统也可能有影响,表现出拟雌激素作用;氧化损伤主要可能的靶器官为肝脏;由于其体内代谢分布特性,免疫干扰表现在多器官中,表现多样;对神经毒性的相关研究发现,邻苯二甲酸二(2-乙基己)酯可上调或下调多种神经因子,可能有多器官的广泛毒性。
Di-（2-ethylhexyl） phthalate, a ubiquitous plasticizer, is an endocrine disruptor with its patho- logical mechanism unclear yet. Studies have proposed that it is likely to have the toxieities of endocrine dis- ruption, oxidative damage, immunological disorders and genetic changes, which may have certain pathways and target organs. Endocrine disruption may refers to certain pathways contributing to the development and functions of male reproductive systems ,as well as the development and functions of female reproductive sys- tems, which indicates that di-（2-ethylhexyl）phthalate acts like estrogens;oxidative damage targets livers; immunological disorders appear at multi-organs in various ways due to the metabolism of di-（2-ethylhexyl） phthalate;and certain neural factors may be up-regulated or down-regulated by di-（2-ethylhexyl） phthalate. Above all, di-（2-ethylhexyl）phthalate may have extensive toxicities in many organs.
出处
《医学综述》
2015年第9期1581-1584,共4页
Medical Recapitulate
