摘要
子痫前期以新发的高血压和蛋白尿为特征,是一种严重的妊娠合并症。其发病机制涉及氧化应激、内皮功能失调、血管收缩、代谢改变、血栓性疾病及免疫反应等。目前的主流观点认为,子痫前期是与遗传和环境因素相关的多基因疾病,并且越来越多的研究发现,母体和胎儿的遗传基因改变是子痫前期发病的重要因素。
Preeclampsia is characterized by newly onset hypertension and proteinuria and is a major pregnancy complication.The pathogenesis involves oxidative stress,endothelial dysfunction,vasoconstriction, metabolic changes, thrombotic disease and immune response,etc.At present the mainstream view is that pre-eclampsia is a polygenic disease associated with genetic and environmental factors ,and a growing number of studies have found that maternal and fetal genetic change is an important factor in the pathogenesis of pre-eclampsia.
出处
《医学综述》
2015年第8期1377-1379,共3页
Medical Recapitulate
关键词
子痫前期
基因
妊娠
Preeclampsia
Gene
Pregnancy
