摘要
目的评价舒芬太尼联合地佐辛用于上腹部手术后患者自控镇痛(PCA)协同作用。方法择期进行上腹部手术患者74例随机分为试验组35例和对照组39例。对照组静脉滴注舒芬太尼2μg·kg-1+昂丹司琼8 mg+0.9%NaCl 100 mL,试验组静脉滴注舒芬太尼1μg·kg-1+地佐辛0.4mg·kg-1+昂丹司琼8 mg+0.9%NaCl 100 mL。分别于术后2,4,8,12,24 h用视觉模糊评分法(VAS)和Ramsay镇静评分法对患者进行镇痛、镇静评价;同时记录2组患者术后24 h内患者自控镇痛次数及不良反应发生率。结果 2组患术后24 h内镇痛、镇静评分差异无统计学意义(P>0.05),各时间段患者自控镇痛有效次数差异无统计学意义(P>0.05)。对照组恶心呕吐、头晕等不良反应发生率为48.72%,显著高于试验组的14.29%(P<0.05)。结论舒芬太尼联合地佐辛用于上腹部术后镇痛效果良好,可显著降低舒芬太尼用量及不良反应发生率。
Objective To assess the synergistic effect of sufentanil combined with dezocine for the post-surgery patient controlled analgesia in patients undergoing upper abdominal surgery.Methods A total of 74 patients who scheduled for upper abdominal surgery were recruited in this study.The included 76 patients were randomized divided into experiment group (n=35) and control group (n=39).Patients in the experiment group were given sufentanil 1 μg · kg -1 +ondansetron 8 mg+dezocine 0.4 mg· kg-1 +0.9%NaCl 100 mL and other those in control group were given sufentanil 2 μg · kg-1 +ondansetron 8 mg +0.9%NaCl 100 mL.The visual analogue scale ( VAS) and Ramsay sedation score were recor-ded at the time points of 2, 4, 8, 12 and 24 h after surgery in both groups.The post-surgery patient controlled analgesia ( PCA) times and adverse drug reactions were recorded and compared between the two groups in 24 h after surgery.Results No statistical difference in VAS and Ramsay score was found in each time points between the two groups ( P 〉0.05 ).The PCA times in the two groups were not statistically different ( P〉0.05).But the total rate of adverse drug reactions in the experiment and control group were 14.29% and 48.72% ( P〈0.05 ).Conclusion Sufentanil combined with dezocine for the post -surgery analgesia has excellent synergistic effect, which can decrease the dosage&amp;nbsp;of sufentanil and risk of developing adverse drug reactions.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第9期705-707,共3页
The Chinese Journal of Clinical Pharmacology
基金
浙江省中医药科学研究基金资助项目(2011ZB142)
关键词
舒芬太尼
地佐辛
术后镇痛
协同作用
sufentanil
dezocine
post-surgery analgesia
synergistic effect