摘要
目的 探究尿微量白蛋白/肌酐比值（UACR）与中青年人群血压的相关性.方法 采用随机抽样法抽取2012年1月至2014年3月期间本院接收治疗的高血压患者200例（年龄18 ～50岁）,并随机抽取200例来本院进行体检的健康志愿者,由专业人员对400例研究对象进行问卷调查、生化指标检测（肾功能、血糖、血脂、血尿酸、UACR等）和体格检查等.首先将400例研究对象根据UACR四分位数由低到高分为4组,分别为1、2、3、4组.其次根据400例研究对象血压高低将其分为正常血压、高血压前期和高血压3组.根据各项测试结果分析UACR和血压分组的相关性.结果 正常血压组、高血压前期、高血压组的UACR水平（中位数：25％分位数～ 75％分位数）分别为0.8（0.6 ～ 1.2） mg/mmol、0.9（0.7～1.4） mg/mmol、1.0 （0.8～1.7） mg/mmol;UACR阳性率分别是0、2.6％和34.7％,3组间UACR水平和UACR阳性率差异均有统计学意义（P＜0.05）.对400例观察对象进行年龄等因素的调整后,发现每个UACR分组的收缩压和舒张压均随着UACR水平升高而上升.在调整400例观察对象的体质量指数、年龄、总胆固醇和低密度脂蛋白胆固醇等因素后,4组间相比较,发现2、3、4组较第1组发生高血压前期与高血压的比值比和95％可信区间分别为0.98（0.80～1.20）、1.29（1.05～1.58）和1.86（1.52 ～2.28）.结论 尿微量白蛋白/肌酐比值和中青年人群高血压前期和高血压的发生呈正相关.
Objective To explore the correlation of urinary albumin/creatinine ratio （urinary albumin-to-creatinine ratio,UACR） and blood pressure in young people.Methods Totally 200 cases of hypertensive patients （aged 18 ～50 years old） from January 2012 to March 2014 and 200 healthy volunteers who had medical examination in our hospital were selected with a random sampling method for staff questionnaires,biochemical tests,and physical examinations.Biochemical tests included kidney function,blood glucose,blood lipids,blood uric acid,and UACR.First,400 cases were divided into four groups （1,2,3,and 4 groups） according to UACR quartiles from low to high.Second,400 cases were divided into three groups according to their blood pressure：normal blood pressure,prehypertension,and hypertension.The correlation of UACR and different groups of blood pressure was analyzed.Results For norm blood pressure group,prehypertension,hypertension,the corresponding UACR level （median：25% ～ 75% quartile） was 0.8 （0.6 ～ 1.2） mg/mmol,0.9 （0.7 ～ 1.4） mg/mmol,1.0 （0.8 ～ 1.7） mg/mmol;positive UACR rate was 0,2.6%,and 34.7%,three groups UACR levels and positive UACR rate index differences were statistically significant （P 〈0.05）.After age factor was adjusted for 400 cases,both systolic and diastolic blood pressures were positively correlated with UACR levels.After body mass index,age,total cholesterol,and low-density lipoprotein cholesterol were adjusted for 400 cases,compared to group 1,the ratio of prehypertension to hypertension （95% confidence intervals） in groups 2,3,and 4 was 0.98 （0.80 ～ 1.20）,1.29 （1.05 ～ 1.58）,and 1.86 1.52 ～2.28）.Conclusions Urinary albumin/creatinine ratio was positively correlated with prehypertension and hypertension in young people.
出处
《中国医师杂志》
CAS
2015年第4期513-515,518,共4页
Journal of Chinese Physician
基金
国家自然科学基金（81000109）
关键词
白蛋白尿
肌酸酐/尿
血压
高血压/尿
Albuminuria
Creatinine/UR
Blood pressure
Hypertension/UR
