摘要
目的探讨血小板抗体检测及交叉配型对血小板输注疗效的影响。方法需输注血小板治疗的患者350例分为既往无输血史(A组,110例)和有输血史(B组,240例)两组,采用固相凝集法检测血小板抗体。其中,血小板抗体阳性99例,61例行给予配合性血小板输注(C组),38例行随机血小板输注(D组);计算输注后1h和24h血小板升高指数(CCI),CCI>4.5×109/L判为输注有效。结果 B组血小板抗体阳性率为37.50%,高于A组的8.18%(P<0.05),且随着输血次数增多而增高。C组血小板输注有效率高于D组(83.61%vs.26.32%)(P<0.05)。结论接受异体输血的患者易产生血小板抗体;对血小板抗体阳性患者实施交叉配型可明显提高血小板输注的有效性。
Objective To investigate the effect of platelet antibody detection and cross typing on the efficacy of platelet transfusion .Methods With solid phase agglutination method ,platelet antibody was detected in 350 patients ,of whom 110 cases had no history of blood transfusion （group A） and 240 cases had a history of blood transfusion （group B） .Platelet transfusion after platelet cross typing was performed in 61 cases with platelet antibody positive （group C ） and that without platelet cross typing was performed in 38 cases with platelet antibody positive（group D） .The corrected count increment （CCI）at one hour and 24 hours after platelet transfusion was calculated .CCI〉4.5 × 109/L was evaluated as the effectiveness .Results The rate of platelet antibody positive was higher in group B than that in group A （37.50% vs .8.18% ）（P〈0 .05） .The effectiveness rate of platelet transfusion was higher in group C than that in group D （83.61% vs .26.32% ）（P〈0 .05） . Conclusion The patients with a history of blood transfusion easily produce platelet antibody .Platelet cross typing can effectively improve the effectiveness rate of platelet transfusion in the patients with platelet antibody positive .
出处
《江苏医药》
CAS
2015年第8期910-912,共3页
Jiangsu Medical Journal
关键词
血小板抗体
血小板配型
输血
Platelet antibody
Platelet cross typing
Blood transfusion
