摘要
目的探讨血清糖类抗原(CA)19-9和CA72-4在胰腺癌诊断中的价值。方法检测169例胰腺癌患者(A组)、35例胰腺良性疾病患者(B组)和41例正常人(C组)血清CA19-9和CA72-4的含量,通过建立Logistic回归模型、绘制受试者工作特征曲线(ROC曲线)并计算曲线下面积(AUC)评价各指标的诊断价值。结果 A组CA19-9和CA72-4水平高于B、C组(P<0.01)。在A与B组、A与C组的ROC曲线中,CA19-9的AUC均大于CA72-4的AUC(P<0.01);逐步Logistic回归后,在A与C组的ROC曲线中,两种标志物联合的AUC高于各自单独检测的AUC(P<0.05或P<0.01);通过ROC曲线确定CA19-9的最佳临界值为174.45U/ml,此时诊断胰腺癌的敏感度为73.37%,特异度为88.57%。结论联合检测血清CA19-9和CA72-4对良恶性胰腺疾病的鉴别诊断具有一定的临床价值。
Objective To explore the value of serum CA19-9 and CA72-4 detection in the diagnosis of pancreatic cancer .Methods Serum levels of CA19-9 and CA72-4 were detected by automatic chemiluminesent immunoassay assay in 169 patients with malignant pancreatic tumors （group A） ,35 patients with benign pancreatic diseases（group B） and 41 normal controls（group C） . Logistic regression and the receiver-operating characteristics curve （ROC curve ） were applied to analyze the data and evaluate the diagnostic values .Results Serum levels of CA19-9 and CA72-4 were significantly higher in group A than those in groups of B and C（P〈0 .01） .The area under ROC curve （AUC） of CA19-9 was larger than that of CA72-4 both in groups of A and B and in groups of A and C（P〈0 .01） .The AUC of combined use of CA19-9 and CA72-4 was larger than that of CA19-9 or CA72-4 alone after stepwise logistic regression analysis in groups of A and C （P〈0 .05 or P〈0 .01） . Taking 174.45 U/ml as the cutoff value of CA19-9 determined by ROC curve ,the sensitivity and specificity in the diagnosis of pancreatic cancer were 73.37% and 88.57% ,respectively .Conclusion Combined detection of serum CA19-9 and CA72-4 is helpful in the differential diagnosis of benign and malignant pancreatic tumors .
出处
《江苏医药》
CAS
2015年第8期892-894,共3页
Jiangsu Medical Journal
基金
国家自然科学基金(81272745)
