摘要
目的 比较几种抗癫痫药物对新诊断癫痫患者的总有效率和保留率.方法 选择2012年1月至2013年5月在晋城市人民医院神经内科就诊的癫痫患者89例.以单药治疗为原则,根据病情采用联合治疗,观察3、6、9、12个月治疗期内癫痫发作频率相对规范治疗前下降的百分比,比较其总有效率,并分析停药原因.对每组患者的日常生活能力进行量表评定和分析.结果 三种抗癫痫药控制癫痫的疗效基本一致,总有效率为79.3％-87％,差异未见统计学意义（P＞0.05）.三种药物的3、6、9、12个月保留率分别为：丙戊酸钠89.2％、81.1％、81.1％、75.7％,卡马西平86.2％、79.3％、72.4％、72.4％,拉莫三嗪91.3％、91.3％、87.0％、87.0％.每季度各组保留率比较差异未见统计学意义（P＞0.05）.停药或换药的主要原因是癫痫控制效果差（15例,75％）,其次是不良反应（4例,20％）.对各组患者治疗前和治疗后12个月日常生活能力量表进行评定,拉莫三嗪组最高,差异有统计学意义（P＜0.05）.结论 三种抗癫痫药的有效性及保留率比较差异未见统计学意义（P＞0.05）,停药原因主要为药物疗效不佳和不良反应,拉莫三嗪可改善患者治疗12个月时日常生活能力.
Objective To investigate the total efficiency and retention rate of different drug treatment for newly diagnosed patients with epilepsy.Methods Eighty-nine patients with epilepsy in Jincheng People＇s Hospital from January 2012 to May 2013 were selected,treated by monotherapy principle and using combination therapy according to the disease.Compared before the standard treatment,the percentage decline of epileptic seizure frequency in 3,6,9,12 months was observed,and the total efficiency,reason for discontinuation,activities of daily living of patients were analyzed.Results Three kinds of anti-epileptic drugs to control epilepsy had basically the same effect and the total effective rate was 79.3% - 87% （P 〉 0.05）.The 3,6,9,12-month retention rates of three drugs：sodium valproate 89.2%,81.1%,81.1%,75.7% ; carbamazepine 86.2%,79.3%,72.4%,72.4%,and Lamotrigine 91.3%,91.3%,87.0%,87.0%.Retention rate in each group was no significant difference on a quarterly basis.The main reason of the withdrawal or dressing were poor seizure control（15 cases,75%） ; followed by adverse reactions（4 cases,20%）.For each group of patients before and after treatment and 12 months were assessed daily living scale,the highest lamotrigine group （P 〈 0.05）.Conclusions Effectiveness and retention rates of three kinds of antiepileptic drugs has no significant difference between the pros and cons,the main reason of the discontinuation are poor drug efficacy and adverse effects.Lamotrigine can improve activities of daily living of patients in treatment for 12 months.
出处
《中国实用医刊》
2015年第10期17-19,共3页
Chinese Journal of Practical Medicine
关键词
癫痫
新诊断
保留率
日常生活能力
Patients with epilepsy
Newly diagnosed
Retention rate
Activities of daily living
