摘要
目的 :观察黄芪注射液对实验性慢性心衰大鼠心肌肥厚的逆转作用。方法 :结扎大鼠腹主动脉造成心肌肥厚模型 ,手术 4周后开始给药 ,连续 8周。分别在手术前、手术后 4周 ,以及给药后的 2周和 8周测量动物血压 ,并在给药 8周后采用心内插管观察心脏血流动力学变化 ,测定心脏重量、左心室肌细胞横切面积以及总蛋白含量。结果 :1、结扎腹主动脉后动物血压持续升高 ,黄芪注射液无显著降低动物血压的作用。 2、黄芪注射液可增强心衰动物的心脏收缩功能 ,使收缩速度加快、收缩时间缩短 ,但对心脏舒张功能无明显改善。 3、黄芪注射液可降低左心室重量指数 (左心室重量 /体重 )。4、黄芪注射液有减小左心室心肌细胞横切面积和降低左心室肌总蛋白含量的作用趋势 ,但与模型组比较无显著性差异。结论 :黄芪注射液可明显改善慢性心衰动物的心脏收缩功能 。
Objective: To investigate the inhibitory effect of Huangqi Injection on experimental cardiac hypertorphy in rats.Methods:42 male SD rats were divided into 4 groups: age machthed control, model, Huangqi Injection group and Captopril group. cardiac hypertrophy was induced by suprarenal abdominal aorta constriction. The drugs were administered for 8 weeks from 4 weeks after surgery at dosage of Huangqi Injection 10g/kg(i.p) and Captopril 50mg/kg(p.o). Blood pressure (BP) was measured 4 times during the period of experiment, and hemodynamics, cardiac index, cell size of left ventricular myocardial and total protein of left ventricular tissue were detected for 8 weeks after treatment with drugs. Results: 1. The BP of the aorta binded rats kept increase in comparison with those of the normal and the age matched control rats, and Huangqi Injection showed no significant effect on it. 2. After 8 weeks treatment with Huangqi Injection, the +dp/dt max was increased and t dp/dt was shortened, which indicated that the ability of heart contraction was enhanced. 3. Left ventricular index (left ventricular weight/body weight) was notably decreased by treatment with Huangqi Injection. 4. The cell size of left ventricular myocardial and total protein of left ventricular showed lightly reduce by Huangqi Injection treatment, but there is no significant difference compared with those of model rats. Conclusion: Huangqi Injection can improve the abnormal cardiac function and may contribute to the prevention of the development of left ventricular hypertrophy induced by pressure overload.
出处
《中成药》
CAS
CSCD
北大核心
2002年第7期525-529,共5页
Chinese Traditional Patent Medicine
