摘要
目的研究miR-128在胃癌中的表达及临床意义。方法采用原位杂交法检测112例胃癌组织及癌旁正常组织的表达,统计分析miR-128与胃癌患者临床参数的关系。结果 miR-128在胃癌中表达下调,在胃癌组织中阳性表达35例,阴性表达77例,而在癌旁正常组织中阳性表达89例,阴性表达23例;与患者的TNM分期相关,TNM I^II期患者中miR-128低表达的42例,高表达28例,TNM III^IV期患者中miR-128低表达的35例,高表达的7例。结论 miR-128在胃癌组织中表达低于癌旁正常组织,与胃癌患者TNM分期,可作为胃癌分期预测的潜在分子标志物。
Objective To identify the expression and clinical significance of miR-128 in gastric cancer. Methods The expression of miR-128 in 112 gastric cancer samples was detected by ISH. The correlation between the expression of miR-128 and clinical parameters was analyzed. Results miR-128 was downregulated in gastric cancer tissues. It negatively correlated to the TNM stage. Conclusion The expression of miR-128 was downregulated in gastric cancer tissues, correlated to TNM stage. miR-128 could be a potential biomarker in evaluating TNM stage, sensitivity to target therapy.
出处
《当代医学》
2015年第14期1-2,共2页
Contemporary Medicine
