摘要
目的综合评价甘露糖结合凝集素（mannose-bindinglectin,MBL）基因多态性与结核易感性关系。方法通过计算机检索中国知网、维普、万方、Pub Med、EMBASE、Web of Science、Cochrane图书馆截止2013年3月国内外公开发表的有关甘露糖结合凝集素基因多态性与结核易感性关系的相关文献。按Cochrane系统评价方法,采用Stata11.0进行Meta分析。结果入选21项病例对照研究包括4161例患者及4955例正常对照者,Meta分析结果显示等位基因模型（OR 0.88,95%CI 0.67~1.16）,共显性模型OO vs.AA（OR 1.39,95%CI 0.80~2.41）;AO vs.AA（OR 1.11,95%CI 0.90~1.38）隐形基因模型：（OR 1.36,95%CI 0.88~2.10）,显性基因模型（OR 1.13,95%CI 0.89~1.44）,总体上,MBL基因多态性与肺结核易感性无显著关联性,但按人种进行亚组分析显示,MBL多态性明显增加了亚洲人群的结核易感性（OO＋AO/AA：OR 1.27 95%CI 1.03~1.56）,但未发现与高加索人群、非洲人群相关。结论 MBL基因多态性增加了亚洲人群结核病易感性。
Objective A comprehensive Meta-analysis was performed to investigate the relationship between mannose-bindinglectin（ MBL） polymorphism and tuberculosis susceptibility. Methods A search for relevant articles published by March,2013 was run on CNKI,Wei Pu,Wang Fang,Pubmed,EMBASE,Web of Science,Cochrane Library. All researches on MBL polymorphism and tuberculosis susceptibility were included. Stata11. 0 software was used for Meta-analysis according to Cochrane system evaluation method.Results Twenty one case-control studies including 4161 cases and 4955 controls were accepted in the Metaanalysis. Overall,there was no significant association was seen between MBL Polymorphism and tuberculosis in every genetic model Such as Allele model（ OR 0. 88,95% CI 0. 67-1. 16）; Codominant model OO vs. AA（ OR1. 39,95% CI 0. 80-2. 41）; AO vs. AA（ OR 1. 11,95% CI 0. 90-1. 38）; Recessive model（ OR 1. 36,95% CI0. 88-2. 10）; Dominant model（ OR = 1. 13,95% CI 0. 89-1. 44）. Significant associations were observed in subgroups of Asian populations（ OO ＋ AO / AA： OR 1. 27 95% CI 1. 03,1. 56）,but were not observed in Caucasian and African populations when stratified by ethnicity. Conclusion MBL Polymorphism may contribute to tuberculosis susceptibility in Asian populations.
出处
《中华肺部疾病杂志（电子版）》
CAS
2015年第2期41-45,共5页
Chinese Journal of Lung Diseases(Electronic Edition)
